肖立华

肖立华教授,博士生导师

 学科:预防兽医学                                      
邮箱地址:lxiao@scau.edu.cn
通讯地址: 广东省广州市天河区五山路483号
简介


美国寄生虫学会杰出贡献奖“Henry Baldwin Ward Medal”获得者。1990年获美国缅因大学博士学位,之后在俄交俄州立大学从事博 士后3年,1993年起在美国疾病预防控制中心工作25年,并长期担任Molecular Epidemiology Laboratory, Waterborne Diseases Prevention Branch Team Leader.

长期从事隐孢子虫等人兽共患病原的研究,是隐孢子虫分子流行病学领域的开拓者。揭示了隐孢子虫的宿主适应性特征,纠正了之前认为的只有一个隐孢子虫虫种的认知,建立了国际公认的虫种命名标准以及虫种和亚型区分方法。阐明了隐孢子虫在全球的传播和扩散机制,提出人 兽共患虫种的传播与集约化养殖密切相关的观点,并揭示了病原人善共患性的潜在遗传基础。 揭示隐孢子虫高致病力亚型的产生源自遗传重组,定位了致病力相关基因区域,为病原主动监测平台的建立提供了科学依据。

在Nature、Cell Host Microbe、Nat Commun、Clin Microbe Rev和Trends Parasitol等領域内权威期刊发表论文520篇 ,H指数97 。 自2018年以来5次入选Web of science 全球高被引科学家榜单。 担 任 Clin Mierobiol Rev和Parasitol Re副主编和其他8个国际期刊编委。为世界各地培养了澳大利亚总理奖获得者、中国杰出青年科学基金获得者和中国“国家百千万人才工程” 入选者等众多优秀科研人员。基于其在领域的突出贡献,曾获美国寄生虫学会杰出成就奖以及中国侨界贡献奖,具有国际公认的学术造诣和影响力。



工作经历


 2018-至今:特聘教授,华南农业大学

1993-2017:副研究员/研究员,美国疾病预防控制中心

1991-1992:博士后,美国俄亥俄州立大学

1985-1987:讲师,东北农业大学


教育经历


1987-1990:博士,美国缅因大学,寄生虫学专业

1982-1985:硕士,中国农业大学,兽医寄生虫学专业

1978-1982:学士,湖南农业大学,兽医学专业


获奖荣誉


2018,2019,2020,2022,2024:Highly Cited Researchers,Web of Science(全球高被引科学家)

2018:Excellence in Laboratory Research,National Center for Emergening and Zoonotic Infectious Diseases,CDC,Atlanta,USA

2004:Unit Citation Award,National Oceanic Atmospheric Administration

2008:CDC Public Health Epidemiology and Laboratory Research Award,Atlanta,USA

2008:NCZVED/CDC Laboratory Science Mentorship Award, Atlanta,USA

2010:Top Cited Article 2008-2010,International Journal for Parasitology, Elsevier

2011:Outstanding Service,American Society for Microbiology Minority Mentoring Program,USA.

2012: Top Cited Article 2009-2011,Experimental Parasitology, Elsevier

2012:美国寄生虫学会杰出成就奖“Henry Baldwin Ward Medal”


社会、学会及学术兼职


2021至今:Animal Disease 副主编

2018-至今:Frontiers in Microbiology副主编

2017-至今:Parasitology Research副主编

2014-2020:Clinical Microbiology Reviews副主编

2019-至今:One Health编委

2018-至今:Veterinary Parasitology编委

2017-至今:Food and Waterborne Parasitology编委

2010-2022:Clinical Microbiology Reviews编委

2014-2022:Journal of Clinical Microbiology编委

2010-2019: Applied and Environmental Microbiology编委

2012-至今:Experimental Parasitology编委

2009:Experimental Parasitology,Special issue特邀编辑

2009-至今:CryptoDB、MicrobeNet、NIH-CDC-HIVMA/IDSA、USEPA SAM Pathogen Methods咨询委员会委员


研究领域


以食源性和水源性病原体(如隐孢子虫、贾第虫、环孢子虫和微孢子虫等)为研究对象,长期从事其病原生物学、分子检测和溯源及生态学研究。主要研究方向包括:

1.食源性、水源性新发病原的生物学、遗传学、分子流行病学和生态学

2.食源性、水源性新发病原的侵入、跨种传播及致病机理

3.食源性、水源性新发病原的比较和功能基因组学及其应用


发表论文


1.Xiao, K., Zhai, J., Feng, Y., Zhou, N., Zhang, X., Zou, J.J., Li, N., Guo, Y., Li, X., Shen, X., Zhang, Z., Shu, F., Huang, W., Li, Y., Zhang, Z., Chen, R.A., Wu, Y.J., Peng, S.M., Huang, M., Xie, W.J., Cai, Q.H., Hou, F.H., Chen, W.*, Xiao, L.*, Shen, Y.*, 2020.Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins. Nature 583, 286-289.

2.Feng Y., Ryan U.M., Xiao L.*, 2018.Genetic diversity and population structure of Cryptosporidium. Trends in parasitology 34, 997-1011.

3.Feng Y.* and Xiao L.*, 2017.Molecular epidemiology of cryptosporidiosis in China. Frontiers in Microbiology 8:1701.

4.Zhang, Q., Guo, Y., Li, N., Li, Y., Su, J., Xu, R., Zhang, Z., Feng, Y.*, Xiao, L.*, 2020.Characterization of Calcium-dependent protein kinases 3,  a protein involved in growth of Cryptosporidium parvum.Frontiers in Microbiology 11, 907.

5.Xu, R., Guo, Y., Li, N., Zhang, Q., Wu, H., Ryan, U., Feng, Y.*, Xiao, L.*, 2019.Characterization of INS-15,  A metalloprotease potentially involved in the invasion of Cryptosporidium parvum.Microorganisms 7.

6.Zhang, S., Chen, L., Li, F., Li, N., Feng, Y.*, Xiao, L.*, 2019.Divergent copies of a Cryptosporidium parvum-specific subtelomeric gene.Microorganisms 7.Su, J., Jin, C., Wu, H., Fei, J., Li, N., Guo, Y., Feng, Y.*, Xiao, L.*, 2019.Differential expression of three Cryptosporidium species-specific MEDLE proteins.Frontiers in Microbiology 10, 1177.

8.Li, N., Wang, R., Cai, M., Jiang, W., Feng, Y.*, Xiao, L.*, 2019.Outbreak  of cryptosporidiosis due to Cryptosporidium parvum subtype IIdA19G1 in neonatal calves on a dairy farm in China.International Journal for Parasitology 47, 569-577.

9.Xu, Z., Guo, Y., Roellig, D.M., Feng, Y.*, Xiao, L.*, 2019.Comparative analysis reveals conservation in genome organization among intestinal Cryptosporidium species and sequence divergence inpotential secreted pathogenesis determinants among major human-infecting species. BMC Genomics 20, 406.

10.Zhang, S., Wang, Y., Wu, H., Li, N., Jiang, J., Guo, Y., Feng, Y.*, Xiao, L.*, 2019.Characterization of a species-specific insulinase-like protease in Cryptosporidium parvum.Frontiers in Microbiology10, 354.

11.Wang, Y., Li, N., Guo, Y., Wang, L., Wang, R., Feng, Y.*, Xiao, L.*, 2018.Persistent Occurrence of Cryptosporidium hominis and Giardia duodenalis Subtypes in a Welfare Institute.Frontiers inmicrobiology 9, 2830.

12.Feng, Y., Gong, X., Zhu, K., Li, N., Yu, Z., Guo, Y., Weng, Y., Kvac, M., Feng, Y.*, Xiao, L.*, 2019.Prevalence and genotypic identification of Cryptosporidium spp.,  Giardia duodenalis andEnterocytozoon bieneusi in pre-weaned dairy calves in Guangdong, China.Parasites & Vectors 12, 41.

13.Liu S., Roellig D.M., Guo Y., Li N., Frace M.A., Tang K., Zhang L.,  Feng Y.*and Xiao L.*(2016)Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium.BMCGenomics, 17:1006.

14.Liu S., Wang L., Zheng H., Xu Z., Roellig D.M., Li N., Frace M.A., Tang K., Arrowood M.J., Moss D.M., Zhang L., Feng Y.*, and Xiao L.*(2016) Comparative genomics reveals Cyclosporacayetanensis possesses coccidia-like metabolism and invasion components but unique surface antigens. BMC Genomics 17, 316.

15.Li P., Cai J., Cai M., Wu W., Li C., Lei M., Xu H., Feng L., Ma J., Feng Y.*, and Xiao L.*(2016)Distribution of Cryptosporidium species in Tibetan sheep and yaks in Qinghai, China.Veterinary Parasitology 215, 58-62.



专著教材


1.Xiao L.,Ryan U.,and Feng Y.(eds)(2015)Biology of Foodborne Parasites.CRC Press,Boca Raton,FL,507 pages.

2.Ryan U.,Power M.,and Xiao L.(eds)(2010) Cryptosporidium and Other Waterborne Protozoa. Experimental Parasitology,Volume 124,Issue 1(Special Issue),146 pages.

3.Fayer R.and Xiao L.(eds)(2008)Cryptosporidium and Cryptosporidiosis,2nd edition,CRC Press and IWA Publishing,Boca Raton,FL,560 pages.

4.Xiao L.,Alderisio K., and Singh A. Development and Standardization of a Cryptosporidium Genotyping Tool for Water Samples.Awwa Research Foundation,Denver,Colorado,2006,116 pages.1P-3.5C-91101-03/06-CM.


教学活动


讲授《兽医寄生虫学(全英)》等课程。


指导学生


已毕业研究生博士研究生14名,硕士研究生20余名。目前指导在读博士研究生6名,硕士研究生12名。


我的团队


所带领的团队包括教授2名,副教授5名,博士后1名。