孙海亮，男，汉族，山东临朐县人，中共党员，博士研究生学历，副教授，硕士生导师。

2016年10月至今华南农业大学兽医学院首聘副教授、副教授。

2014年9月至2016年6月美国密西西比州立大学兽医学院研究助理教（Faculty）。

2011年9月至2014年9月美国密西西比州立大学兽医学院博士后 (Staff) 。

教育经历2011年6月 华南农业大学兽医学院预防兽医专业，获博士学位。

2008年6月 甘肃农业大学兽医学院预防兽医专业，获硕士学位。

2005年6月 河南农业大学牧医工程学院动物医学专业，获学士学位。

禽流感等禽重要病毒病的基础与应用研究、新型疫苗研发、新发传染病研究。

1.十四五国家重点研发计划子课题：禽重要病毒病mRNA疫苗创制，在研，主持；

2.十四五国家重点研发计划子课题：高致病性禽流感与新城疫现场抗原快检技术及产品，在研，主持；

3.广东省自然科学基金：EBBP蛋白调节SQSTM1-NRF2-KEAP1轴影响禽流感病毒复制的分子机制，在研，主持；

4.广东省自然科学基金：AIV调控MARCH5介导FUNDC1依赖性线粒体自噬，重编程细胞能量代谢促进自身复制的分子机制，在研，主持；

5.广东省自然科学基金：受体嗜性改变推进H9N2 AIV抗原变异，结题，主持；

6.广东省教育厅特色创新项目：猪H1亚型流感病毒耐酸性增强的分子基础，结题，主持；

7.国家自然科学基金重点项目：H9N2亚型禽流感病毒激活鸡T细胞免疫应答的分子机制，结题，排名第4；

8.国家重点研发计划子项目：水禽疫苗细胞悬浮培养、细菌高密度发酵、耐热保护剂等关键新工艺研究与应用，结题，排名第2；

1. Sun H, Liu H, Zhang J, Qu X, Pang Z, Xu F, Wu C, Jiang Y, Shi M, Liu Q, Liao M. Genome-scale evolution and phylodynamics of swine influenza A viruses in China: a genomic epidemiology study. Lancet Microbe. 2025 Apr 28:101020. doi: 10.1016/j.lanmic.2024.101020. Epub ahead of print. PMID: 40311646.

2.Hailiang Sun, Zifeng Pang, Cuishan Mai, Hejie Wang, Yutan Yang, Junkun Fan, Peiting Zhong, Wenrui Yan and Ming Liao.Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals.Animals and Zoonoses.2025;1:69-85.

3. Wei Y, Gu Y, Zhou Z, Wu C, Liu Y, Sun H. TRIM21 Promotes Oxidative Stress and Ferroptosis through the SQSTM1-NRF2-KEAP1 Axis to Increase the Titers of H5N1 Highly Pathogenic Avian Influenza Virus. International journal of molecular sciences. 2024;25(6).

4. Cui X, Ma J, Pang Z, Chi L, Mai C, Liu H, et al. The evolution, pathogenicity and transmissibility of quadruple reassortant H1N2 swine influenza virus in China: A potential threat to public health. Virologica Sinica. 2024;39(2):205-17.

5. Liu Y, Wei Y, Zhou Z, Gu Y, Pang Z, Liao M, et al. Overexpression of TRIM16 Reduces the Titer of H5N1 Highly Pathogenic Avian Influenza Virus and Promotes the Expression of Antioxidant Genes through Regulating the SQSTM1-NRF2-KEAP1 Axis. Viruses. 2023;15(2).

6. Yang X, Sun H, Zhang Z, Ou W, Xu F, Luo L, et al. Antiviral Effect of Ginsenosides rk1 against Influenza a Virus Infection by Targeting the Hemagglutinin 1-Mediated Virus Attachment. International journal of molecular sciences. 2023;24(5).

7. Li W, Song Y, Du Y, Huang Z, Zhang M, Chen Z, et al. Duck TRIM29 negatively regulates type I IFN production by targeting MAVS. Frontiers in immunology. 2022;13:1016214.

8. Liu H, Pang Z, Liu Q, Sun H, Liao M. 2022 outbreak of human mpox: Dissemination and evolution dynamic. Journal of medical virology. 2023;95(5):e28744.

9. Sun H, Wang Y, Liu H, Pang Z, Cui X, Zhao R, et al. The genetic diversity, replication, and transmission of 2009 pandemic H1N1 viruses in China. Frontiers in microbiology. 2023;14:1110100.

10. Sun H, Wang A, Wang L, Wang B, Tian G, Yang J, et al. Systematic Tracing of Susceptible Animals to SARS-CoV-2 by a Bioinformatics Framework. Frontiers in microbiology. 2022;13:781770.

11. Sun HL, Yang JL, Zhang T, Long LP, Jia K, Yang GH, et al. Using Sequence Data To Infer the Antigenicity of Influenza Virus. mBio. 2013;4(4).

12. Sun H, Liu H, Liu Y, Pang Z, Jiang Y, Liu Q, et al. Genetic characterization of a novel quadruple reassortant influenza A (H1N2) virus from swine, China, 2021. The Journal of infection. 2022.

13. Sun H, Cui P, Song Y, Qi Y, Li X, Qi W, et al. PB2 segment promotes high-pathogenicity of H5N1 avian influenza viruses in mice. Frontiers in microbiology. 2015;6:73.

14. Li S, Zhao R, Yang Q, Wu M, Ma J, Wei Y, et al. Phylogenetic and pathogenic characterization of current fowl adenoviruses in China. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2022;105:105366.

15. Sun HL, Jiao PR, Jia BQ, Xu CG, Wei LM, Shan F, et al. Pathogenicity in quails and mice of H5N1 highly pathogenic avian influenza viruses isolated from ducks. Veterinary microbiology. 2011;152(3-4):258-65.

16. Xu Y, Cao H, Liu H, Sun H, Martin B, Zhao Y, et al. Identification of the source of A (H10N8) virus causing human infection. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2015;30:159-63.

17. Liu H, Wu C, Pang Z, Zhao R, Liao M, Sun H. Phylogenetic and Phylogeographic Analysis of the Highly Pathogenic H5N6 Avian Influenza Virus in China. Viruses. 2022;14(8).

18. Sun H, Xue JL, Bailey E, Xu Y, Hu G, Baroch J, et al. A quantitative RT-PCR assay for rapid detection of Eurasian-lineage H10 subtype influenza A virus. Virologica Sinica. 2016;31(5):444-7.

19. Zhang X, Sun H, Cunningham FL, Li L, Hanson-Dorr K, Hopken MW, et al. Tissue tropisms opt for transmissible reassortants during avian and swine influenza A virus co-infection in swine. PLoS pathogens. 2018;14(12):e1007417.

20. Sun H, Lin J, Liu Z, Yu Y, Wu M, Li S, et al. Genetic, Molecular, and Pathogenic Characterization of the H9N2 Avian Influenza Viruses Currently Circulating in South China. Viruses. 2019;11(11).

21. Yu Y, Wu M, Cui X, Xu F, Wen F, Pan L, et al. Pathogenicity and transmissibility of current H3N2 swine influenza virus in Southern China: A zoonotic potential. Transboundary and emerging diseases. 2021.

22. Sun H, Cunningham FL, Harris J, Xu Y, Long LP, Hanson-Dorr K, et al. Dynamics of virus shedding and antibody responses in influenza A virus-infected feral swine. The Journal of general virology. 2015;96(9):2569-78.

23. Sun HL, Jiao PR, Cheng YQ, Yuan RY, Cui PF, Jin LM, et al. The Pathogenicity Variation of Two Quail-Origin H5N1 HPAV to BALB/c Mice after Six Passages in Quail. J Anim Vet Adv. 2011;10(15):1974-80.

24. Wu M, Su R, Gu Y, Yu Y, Li S, Sun H, et al. Molecular Characteristics, Antigenicity, Pathogenicity, and Zoonotic Potential of a H3N2 Canine Influenza Virus Currently Circulating in South China. Frontiers in microbiology. 2021;12:628979.

25. Sun H, Blackmon S, Yang G, Waters K, Li T, Tangwangvivat R, et al. Zoonotic Risk, Pathogenesis, and Transmission of Avian-Origin H3N2 Canine Influenza Virus. Journal of virology. 2017;91(21).

26.Liu Y, Li S, Sun H, Pan L, Cui X, Zhu X, et al. Variation and Molecular Basis for Enhancement of Receptor Binding of H9N2 Avian Influenza Viruses in China Isolates. Frontiers in microbiology. 2020;11:602124.

1.国家发明专利：一种多价禽腺病毒卵黄抗体的制备方法。

2.国家发明专利：一株H9N2亚型禽流感病毒MDCK细胞冷适应减毒活疫苗株及其应用。

1. 广东省农业技术推广奖一等奖（2017）：禽流感灭活疫苗（H5N2亚型D7株）的推广与应用。

2. 广东省农业技术推广奖一等奖（2021）：新型高致病性禽流感灭活疫苗及综合防控技术推广与应用。

态度决定高度，细节决定成败！