王衡，华南农业大学兽医学院副教授，广东省高等院校优秀青年教师，广东省畜牧兽医学会杰出科技工作者，国家非洲猪瘟区域实验室（广州）及华南农业大学动物疾病检测诊断中心成员，全国饲料评审委员会委员（安全风险评估专业组），广东省畜牧兽医学会猪病学分会秘书，中国动物病理学家学会成员。作为第一或通讯作者在国内外期刊发表科技论文60余篇，其中Plos Pathog、Nature Communications、PNAS、J Virol、Microbiol Spectr、Vet Res等国外期刊收录30余篇。曾获华南农业大学“青年教师教学优秀奖”（2017）、华南农业大学“教书育人”先进个人称号（2018）、华南农业大学“双带头人”教师党支部书记素质能力大赛二等奖（2023）。

2004/09-2009/06，东北农业大学，动物医学院，硕士、博士

1999/09-2004/06，东北农业大学，动物医学院，本科

2009/07-至今，华南农业大学，兽医学院，副教授

2014/06-2015/06，美国弗吉尼亚理工大学（Virginia Polytechnic Institute and State University），兽医学院，访问学者

主要从事猪病诊断与防控、猪场生物安全、重要病毒性猪病发病机制、动物病理学等研究。

1.国家重点研发计划，2022YFD1802103，“揭榜挂帅”项目“药物靶标发现与新兽药创制”子课题“抗病毒新药靶标的发现及兽药筛选”，2022/11/01-2027/11/01，110万，在研，主持

2.广东省重点领域研发计划项目，2019B020211005，“非洲猪瘟精准检测技术研究及应用”子项目，2019/6/01-2022/5/31，50万，结题，主持

3.广东省科技厅，2018A030313712，长链非编码RNANEAT1与PRRSV相互作用机制的研究， 2018/11/03-2021/04/30，10万，结题，主持

4.广东省高等学校优秀青年教师培养计划，YQ201530，基于液相芯片技术建立多重猪病毒性传染病病原体抗血清检测方法的研究，2016/01-2018/12，30万元，结题，主持

5.国家自然科学基金青年基金，31201876，II型PRRSV重要抗原表位的筛选及其生物学功能的研究，2013/01-2015/12，21万元，结题，主持

(1)Qiumei Wang, Heyou Yi, Anli Chen, Tao Tian, Zhiqing Yu, Lechen Lu, Ruirui Ye, Ermin Xie, Guoxin Zheng, Guihong Zhang, Heng Wang*. RAP1 is essential for PRRSV replication and the synthesis of the viral genome.Veterinary Microbiology. 2025.301:110361. 

(2)Zhao Huang, Cuiying Kong, WenBo Zhang, Jianyi You, Chenyang Gao, Jiangnan Yi, Zhanzhuo Mai, Xiongnan Chen, Pei Zhou, Lang Gong, Guihong Zhang, Heng Wang*. pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection. PLoS Pathog. 2024. 20(10): e1012613. 

(3)Xing Liu, Ermin Xie, Jingyu Wang, Luling Yan, Tao Tian, Jianyi You, Lechen Lu, Zhicheng Qian, Zemin Tan, Jiansheng Xiong, Lang Gong, Guihong Zhang, Haoshu Luo, Heng Wang*. RpIFN-λ1 alleviates the clinical symptoms of porcine epidemic diarrhea. International Journal of Biological Macromolecules. 2024. 282: 136712.

(4)Yankuo Sun, Jiabao Xing, Samuel L. Hong, Nena Bollen, Sijia Xu, Yue Li,  Jianhao Zhong, Xiaopeng Gao, Dihua Zhu, Jing Liu, Lang Gong, Lei Zhou,  Tongqing An, Mang Shi, Heng Wang*, Guy Baele & Guihong Zhang. Untangling lineage introductions, persistence and transmission drivers of HP-PRRSV sublineage 8.7. Nature Communications. 2024. 15: 8842.

(5)Qianwen Wu, Xing Liu, Jingyu Wang, Sijia Xu, Fanliang Zeng, Ling Chen, Guihong Zhang, Heng Wang*.  An isothermal nucleic acid amplification-based enzymatic recombinase amplification method for dual detection of porcine epidemic diarrhea virus and porcine rotavirus A. Virol. 2024. 20: 594:110062.

(6)Heyou Yi, Ruirui Ye, Ermin Xie, Lechen Lu, Qiumei Wang, Shaojun Wang, Yankuo Sun, Tao Tian, Yingwu Qiu, Qianwen Wu, Guihong Zhang, Heng Wang*. ZNF283, a Krüppel-associated box zinc fnger protein, inhibits RNA synthesis of porcine reproductive and respiratory syndrome virus by interacting with Nsp9 and Nsp10. Vet Res. 2024. 55:9 

(7)Han Gao, Dongdong Di, Qianwen Wu, Jie Li, Xing Liu, Zhiying Xu, Sijia Xu, Chengyu Wu, Lang Gong, Yankuo Sun, Guihong Zhang, Hongjun Chen, Heng Wang*. Pathogenicity and horizontal transmission evaluation of a novel isolated African swine fever virus strain with a three-large-fragment-gene deletion. Vet Microbiol. 2024. 290:110002. 

(8)Yanchen Guo, Yang Chen, Qiumei Wang, Zhiyuan Wang, Lang Gong, Yankuo Sun, Zebu Song, Hao Chang, Guihong Zhang, Heng Wang*. Emodin and rhapontigenin inhibit the replication of African swine fever virus by interfering with virus entry. Vet Microbiol. 2023. 284:109794.

(9)Yingnan Liu, Zhou Shen, Zhenhua Xie, Yingying Song, Yao Li, Rui Liang, Lang Gong, Dongdong Di, Jianqi Liu, Jingyi Liu, Zongyan Chen, Wanqi Yu, Lu Lv, Qiuping Zhong, Xinxin Liao, Chuanwen Tian, Rongrong Wang, Qingqing Song, Heng Wang*, Guiqing Peng, Hongjun Chen. African swine fever virus I73R is a critical virulence-related gene: A potential target for attenuation. Proc Natl Acad Sci U S A. 202. 120(15):e2210808120.

(10)Sijia Xu, Jing Liu, Jiabao Xing, Han Gao, Dihua Zhu, Zhiying Xu, Jianhao Zhong, Yue Li, Xiaopeng Gao, Qiyuan Kuang, Guihong Zhang, Heng Wang*, Yankuo Sun. A Longitudinal Study of NADC34-Like Strains in an Intensive Farm Unravels Divergent Evolution. Transboundary and Emerging Diseases. 2023. 2023: 1-15.

(11)Yingnan Liu, Zhenhua Xie, Yao Li, Yingying Song, Dongdong Di, Jingyi Liu, Lang Gong, Zongyan Chen, Jinxian Wu, Zhengqin Ye, Jianqi Liu, Wanqi Yu, Lu Lv, Qiuping Zhong, Chuanwen Tian, Qingqing Song, Heng Wang*, Hongjun Chen. Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs. Emerg Microbes Infect. 2023. 12(1):2148560.

(12)Qiumei Wang, Heyou Yi, Yanchen Guo, Yankuo Sun, Zhiqing Yu, Lechen Lu, Ruirui Ye, Ermin Xie, Qianwen Wu, Yingwu Qiu, Weipeng Quan, Guihong Zhang, Heng Wang*. PCNA promotes PRRSV replication by increasing the synthesis of viral genome. Vet Microbiol. 2023. 281:109741.

(13)Heyou Yi, Qiumei Wang, Lechen Lu, Ruirui Ye, Ermin Xie, Zhiqing Yu, Yankuo Sun, Yao Chen, Mengkai Cai, Yingwu Qiu, Qianwen Wu, Jie Peng, Heng Wang*, Guihong Zhang. PSMB4 Degrades the Porcine Reproductive and Respiratory Syndrome Virus Nsp1α Protein via the Autolysosome Pathway and Induces the Production of Type I Interferon. J Virol. 2023. 97(4):e0026423.

(14)Yankuo Sun, Zhiying Xu, Han Gao, Sijia Xu, Jing Liu,  Jiabao Xing,  Qiyuan Kuang, Yan Chen, Heng Wang*, Guihong Zhang. Detection of a Novel African Swine Fever Virus with Three Large-Fragment Deletions in Genome, China. Microbiol Spectr. 2022. 02155-22.

(15)Yang Chen, Yanchen Guo, Zebu Song, Hao Chang, Qiyuan Kuang, Zezhong Zheng, Heng Wang*, Guihong Zhang. Luteolin restricts ASFV replication by regulating the NF-κB/STAT3/ATF6 signaling pathway. Vet Microbiol. 202. 273:109527

(16)马俊, 王志远, 梁杏玲, 郑泽中, 杨汉春,张桂红, 王衡*. 基于非洲猪瘟病毒p30与p54蛋白表位串联多肽的间接ELISA抗体检测方法的建立. 畜牧兽医学报. 2022, 53(12): 4325-4336. 

(17)Zhao Huang, Lang Gong, Zezhong Zheng, Qi Gao, Xiongnan Chen, Yang Chen, Xiaojun Chen, Runda Xu, Jiachen Zheng, Zhiying Xu, Shengxun Zhang, Heng Wang*, Guihong Zhang. GS-441524 inhibits African swine fever virus infection in vitro. Antiviral Res. 2021,109: 105081

(18)Yingnan Liu, Yao Li, Zhenhua Xie, Qingying Ao, Dongdong Di, Wanqi Yu, Lu Lv, Qiuping Zhong, Yingying Song, Xinxin Liao, Qingqing Song, Heng Wang*, Hongjun Chen. Development and in vivo evaluation of MGF100-1R deletion mutant in an African swine fever virus Chinese strain. Vet Microbiol. 2021, 261:109208. 

(19)Jingyu Wang, Lang Gong, Weidong Zhan, Wanli Chen, Haoming Pan, Yuchen Zeng, Xingling Liang, Jun Ma, Guihong Zhang, Heng Wang. Wnt/β-catenin signaling pathway inhibits porcine reproductive and respiratory syndrome virus replication by enhancing the nuclear factor-κB-dependent innate immune response. Vet Microbiol. 2020, 251(108904).

(20)Yankuo Sun, Qi Li, Zhiqing Yu, Xiaoliangan, Yingfangei, Chihai Ji, Gang Lu,  Chunquan Ma, Guihong Zhang, Heng Wang*. Emergence of novel recombination lineage 3 of porcine reproductive and respiratory syndrome viruses in Southern China. Transbound Emerg Dis. 2018. 00:1-10  

(21)Xinliang Fu, Bo Fang, Yixing Liu, Mengkai Cai, Junming Jun, Jun Ma, Dexin Bu, Lifang Wang, Pei Zhou, Heng Wang*, Guihong Zhang. Newly emerged porcine enteric alphacoronavirus in southern China: Identification, origin and evolutionary history analysis. Infect Genet Evol. 2018. 62: 179–187

(22)Wanli Chen, Jin Cui, Jingyu Wang, Yankou Sun, Chihai Ji, Ruyue Song, Yuchen Zeng, Haoming Pan, Jinliang Sheng, Guihong Zhang, Heng Wang*. Phages bearing specific peptides with affinity for porcine reproductive and respiratory syndrome virus GP4 protein prevent cell penetration of the virus. Vet Microbiol. 2018. 224: 43–49

1)王衡; 郭彦辰; 张桂红; 龚浪; 陈洋; 孙彦阔; 郑泽中; 丹叶大黄素在制备防治非洲猪瘟病毒的药物中的应用，2021-07-22, 中国, ZL 202110832036.6. 

2)王衡; 张桂红; 曾梦; 冀池海; 一种伪狂犬病毒gE和Gb IgG 抗体双重荧光微球免疫学检测方法, 2021-12-24, 中国, 201811192108.X.

3)王衡; 宋雪梅; 张桂红; 杨奎亮; 卢刚; 李中圣; 一种非洲猪瘟核酸试纸条检测试剂盒, 2020-10-23, 中国, ZL201910689509.4. 

4)王衡; 张桂红; 纪方晓; 冀池海; 曾梦; 陈万里; 一种猪PRRSV、SIV、HEV抗体的液相芯片多重检测试剂盒, 2018-5-1, 中国, ZL201611015332.2. 

5)王衡; 张桂红; 纪方晓; 陈济铛; 梁焕斌; 朱婉君; 古洪浪; 一种猪戊型肝炎病毒ORF2重组蛋白的制备方法及其ORF2蛋白和检测试剂盒, 2013-5-1, 中国, ZL20161101584 5.3. 

6)张桂红; 王衡; 记方晓; 孙彦阔; 冀池海; 曾梦; 一种猪H1N1亚型流感病毒血凝素重组蛋白的制备方法及该病毒抗体的液相芯片检测试剂盒, 2016-11-18, 中国, CN201611015852.3.  

7)张桂红; 王衡; 梁焕斌; 宁章勇; 古洪浪; 纪方晓; 戊型肝炎病毒抗体检验通用ELISA法及其应用, 2014-6-4, 中国, CN201310556500.9.

非洲猪瘟病毒核酸恒温荧光扩增检测试剂盒获批注册（中华人民共和国农业农村部公告 第619号）

诚实做人，踏实做事。