个人详细情况

    李娜，女，1981年5月出生于河南省开封市，理学博士，副教授。

    2011年在同济大学获得生物医学工程专业博士学位，此后在Centers for Disease Control and Prevention (USA)从事2年博士后研究。2013年起在华东理工大学任讲师，2017年起在华南农业大学任副教授。

    十多年来从事人兽共患寄生虫（隐孢子虫、贾第虫、环孢子虫和微孢子虫等）的病原生物学、分子生物学以及群体遗传学研究。在发掘宿主适应性遗传决定因素、解析与毒力相关的致病机制、筛选药物疫苗分子靶标等方面开展了系列研究工作。相关研究成果已发表SCI论文23篇，包括领域权威期刊Emerg Infect Dis （2篇第一作者）、PLoS Neglect Trop Dis、BMC Genomics、Parasite Vector和J Clin Microbiol等，引用次数累计超过300次。在国内外学术会议上作报告十余次。

学历及培训经历：

2011年01月－2012年10月  Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, USA  博士后

2008年01月－2010年12月  Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, USA  博士联合培养

2007年03月－2011年01月  同济大学生命科学与技术学院生物医学工程专业  博士

2003年09月－2006年06月  郑州大学物理工程学院生物物理专业  硕士

1999年09月－2003年06月  河南师范大学生命科学学院生物技术专业  学士

工作经历：

2017年03月－至今  华南农业大学兽医学院  副教授

2013年03月－2017年02月  华东理工大学资源与环境工程学院  讲师

研究领域：

• 宿主适应性的遗传决定因素

• 与毒力和入侵相关的致病机制

• 药物和疫苗分子靶标的筛选

• 分子检测和溯源

承担科研项目情况：

• 国家自然科学基金青年科学基金项目：泛在隐孢子虫的种内宿主适应性和地理隔离性研究（31302078），2014-2016，主持

• 家畜疫病病原生物学国家重点实验室开放基金项目：泛在隐孢子虫高分辨力溯源新方法的研究（SKLVEB2014KFKT008），2014-2016，主持

• 中央高校基本科研业务费探索研究专项基金项目：新发人兽共患病原——泛在隐孢子虫在人与动物及环境之间的传播机制研究（WB1314053），2013-2015，主持

• 国家自然科学基金重点项目：胰岛素降解酶在隐孢子虫入侵中的作用机制（31630078），2017-2021，参加

• 国家自然科学基金国家杰出青年科学基金项目：兽医寄生虫学（31425025），2015-2019，参加

代表论著：（*通讯作者）

1.Li, N., Xiao, L., Alderisio, K., Elwin, K., Cebelinski, E., Chalmers, R., Santin, M., Fayer, R., Kvac, M., Ryan, U., Sak, B., Stanko, M., Guo, Y. Q., Wang, L., Zhang, L. X., Cai, J. Z., Roellig , D., Feng, Y.* Subtyping Cryptosporidium ubiquitum, a zoonotic pathogen emerging in humans. Emerging Infectious Diseases. 20: 217-224, 2014

2.Li, N., Xiao, L., Cama, V., Ortega, Y., Gilman, R. H., Guo, M., Feng, Y.* Genetic recombination and Cryptosporidium hominis virulent subtype IbA10G2. Emerging Infectious Diseases. 19: 1573-1582, 2013

3.Li, N., Xiao, L., Wang, L., Zhao, S. M., Zhao, X. K., Duan, L. P., Guo, M. J., Liu, L. L., Feng, Y.* Molecular surveillance of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi by genotyping and subtyping parasites in wastewater. PLoS Neglected Tropical Diseases. 6: e1809, 2012

4.Li, N., Neumann, N. F., Ruecker, N., Alderisio, K. A., Sturbaum, G. D., Villegas, E. N., Chalmers, R., Monis, P., Feng, Y.Y., Xiao, L.* Development and evaluation of three real-time PCR assays for genotyping and source tracking Cryptosporidium in water. Applied and Environmental Microbiology. 81: 5845-5854, 2015

5.Li, N., Ye, J. B., Arrowood, M. J., Ma, J. B., Wang, L, Xu, H. L., Feng Y.*, Xiao, L. Identification and morphologic and molecular characterization of Cyclospora macacae n. sp. from rhesus monkeys in China. Parasitology Research. 114: 1811-1816, 2015

6.Tang, Y.†, Li, N. †（共同第一作者）, Song, M., Roellig, D. M., Feng, Y., Xiao, L.* Development of a multilocus sequence typing tool for high-resolution subtyping and genetic structure characterization of Cryptosporidium ubiquitum. Infection Genetics and Evolution. 45: 256-261, 2016

7.Xu, H., Jin, Y., Wu, W., Li, P., Wang, L., Li, N.*, Feng, Y.*, Xiao, L. Genotypes of Cryptosporidium spp., Enterocytozoon bieneusi and Giardia duodenalis in dogs and cats in Shanghai, China. Parasites & Vectors. 9: 121, 2016

8.Feng, L., Liu, S., Wu, W., Ma, J., Li, P., Xu, H., Li, N.*, Feng, Y. Dominant genera of cyanobacteria in Lake Taihu and their relationships with environmental factors. Journal of Microbiology. 54: 468-476, 2016

9.Liu, S., Roellig, D. M., Guo, Y., Li, N., Frace, M. A., Tang, K., Zhang, L., Feng, Y.*, Xiao, L.* Evolution of mitosome metabolism and invasion-related proteins in Cryptosporidium. BMC Genomics. 17: 1006, 2016

10.Guo, Y., Roellig, D. M., Li, N., Tang, K., Frace, M., Ortega, Y., Arrowood, M. J., Feng, Y., Qvarnstrom, Y., Wang, L., Moss, D. M., Zhang, L., Xiao, L. Multilocus sequence typing tool for Cyclospora cayetanensis. Emerging Infectious Diseases. 22: 1464-1467, 2016

11.Liu, S., Wang, L., Zheng, H., Xu, Z., Roellig, D. M., Li, N., Frace, M. A., Tang, K., Arrowood, M. J., Moss, D. M., Zhang, L., Feng, Y.*, Xiao, L.* Comparative genomics reveals Cyclospora cayetanensis possesses coccidia-like metabolism and invasion components but unique surface antigens. BMC Genomics. 17: 316, 2016

12.Tang, K., Guo, Y. Q., Zhang, L. X., Rowe, L. A., Roellig, D. M., Frace, M. A., Li, N., Liu, S. Y., Feng, Y.*, Xiao, L.* Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in apicoplast and mitochondrial genomes. Parasites & Vectors. 8: 358, 2015

13.Guo, Y. Q., Tang, K., Rowe, L., Li, N., Roellig, D. M., Knipe, K., Frace, M., Yang, C. F., Feng, Y.*, Xiao, L.* Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum. BMC Genomics. 16: 320, 2015

14.Guo, Y. Q., Li, N., Lyseen, C., Frace, M., Tang, K., Sammons, S., Roellig, D., Feng, Y.*, Xiao, L.* Isolation and enrichment of Cryptosporidium DNA and verification of DNA purity for whole genome sequencing. Journal of Clinical Microbiology. 53: 641-647, 2015

15.Feng, Y.*, Tiao, N., Li N., Hlavsa, M., Xiao, L.* Multilocus sequence typing of an emerging Cryptosporidium hominis subtype in the United States. Journal of Clinical Microbiology. 52: 524-530, 2014

16.Feng, Y.*, Torres E., Li N., Wang L., Bowman, D., Xiao, L. Population genetic characterization of dominant Cryptosporidium parvum subtype IIaA15G2R1. International Journal for Parasitology. 43: 1141-1147, 2013

17.Amera, S. Zidanc, S., Feng, Y. Adamua, H., Li, N., Xiao, L.* Identity and public health potential of Cryptosporidium spp. in water buffalo calves in Egypt. Veterinary Parasitology. 191: 123-127, 2013

18.Feng, Y.*, Li, N., Dearen, T., Lobo, M. L., Matos, O., Cama, V., Xiao, L.* Development of a multilocus sequence typing tool for high resolution genotyping of Enterocytozoon bienuesi. Applied and Environmental Microbiology. 77: 4822-4828, 2011

19.Feng, Y.*, Lal, A. A., Li, N., Xiao, L.* Subtypes of Cryptosporidium spp. in mice and other small mammals. Experimental Parasitology. 127: 238-242, 2011

20.Feng, Y.*, Zhao, X. K., Chen, J. X., Jin, W., Zhou, X. N., Li, N., Wang, L., Xiao, L.* Occurrence, source, and human infection potential of Cryptosporidium and Giardia spp. in source and tap water in Shanghai, China. Applied and Environmental Microbiology. 77: 3609-3616, 2011

21.Feng, Y.*, Yang, W. L., Ryan, U., Zhang, L. X., Kváč, M., Koudela, B., Li, N., Fayer, R., Xiao, L.* Development of a multilocus sequence typing tool for Cryptosporidium muris and Cryptosporidium andersoni. Journal of Clinical Microbiology. 49: 34-41, 2011

22.Shi, K., Jian, F., Lv, C., Ning, C., Zhang, L., Ren, X., Dearen, T., Li, N., Qi, M., Xiao, L.* Prevalence, genetic characteristics, and zoonotic potential of Cryptosporidium species causing infections in farm rabbits in China. Journal of Clinical Microbiology. 48: 3263-3266, 2010

23.Feng, Y., Li, N., Duan, L. P., Xiao, L.* Cryptosporidium genotype and subtype distribution in raw wastewater in Shanghai, China: evidence for possible unique Cryptosporidium hominis transmission. Journal of Clinical Microbiology. 47: 153-157, 2009

写给学生的话：

    心有所愿，无事不成！