蒋红霞

蒋红霞

 学  科:	基础兽医学
电话/传真:	020-85283934/13380055663 
电子邮件:	hxjiang@scau.edu.cn
通讯地址:	广州市天河区五山路483号
华南农业大学兽医学院 510642
简介


蒋红霞,1968年6月出生于新疆库尔勒,女,博士,教授,博士生导师 

现任国家兽医微生物耐药性风险评估实验室副主任,兼任中国畜牧兽医学会兽医药理与毒理学分会副秘书长

2002年在华南农业大学获得基础兽医学农学博士学位,同年留校于华南农业大学任教,2013年晋升教授。一直从事细菌耐药性和兽药安全评价研究。主持和参加“十三五”国家重点研发计划、国家重点基础研究发展计划(973计划)项目、国家自然科学基金、NSFC-广东联合基金重点项目、广东省自然科学基金团队项目等科研项目十多项,发表论文60多篇,其中发表SCI收录论文30余篇。出版国内、外专著、译著、科普书4部。获广东省科学技术奖励一等奖、二等奖各1项,获得发明专利四项。


简历


2019年06-09月 美国肯塔基大学生物化学系,高级访问学者

2009 年 02 月-2010 年 02 月 英国伯明翰大学医学院抗生素耐药性研究实验室 访问学者 

1999 年 09 月-2002 年 06 月 华南农业大学兽医学院 博士研究生

1996 年 09 月-1999 年 06 月 华南农业大学兽医学院 硕士研究生

1987 年 09 月-1991 年 06 月 塔里木农垦大学牧医系 本科生


工作经历


  2002年07月-现在 华南农业大学兽医学院,教授(2013年),兽医药理教研室主任(2008年至2015年),国家兽医微生物耐药性风险评估实验室副主任(2014年至今)

  1991年07月-1996年07月 塔里木农科大学牧医系,讲师


研究领域


•动物源细菌耐药性及适应性研究

•耐氟喹诺酮类沙门氏菌外排泵调控及功能研究

•动物源细菌耐药性风险评估与控制


承担科研项目情况


1. 广东省自然科学基金团队项目-畜禽重要病原菌耐药机制及防控技术研究(S2012030006590) ,2012,10-2017,10,核心主持。

2. 973计划项目:畜禽病原菌重要耐药基因的传播机制与流行规律(2013CB127203),2013-2017年,主要参与。

3.NSFC-广东省联合基金项目:抗菌药残留对动物病原菌耐药性产生和传播的影响研究(U1201214),2013-2016年,主要参与。

4.国家自然科学基金面上项目:RamA与MarA和SoxRS对沙门菌AcrAB-TolC外排泵表达的协同调控机制(31272602),2013-2016年,主持。

5. 广州市科技计划项目:AcrB突变对沙门氏菌外排活性及细菌侵袭力的影响(20160701269),2016/4-2018/3,主持。

6. 国家重点研发计划:畜禽病原菌耐药性评价标准研究(2016YFD0501302),2016-2020年,子课题主持。

7. 国家自然科学基金面上项目:多重耐药沙门氏菌AcrB突变对AcrB-TolC外排泵转运功能的影响(31772792),2018-2021年,主持。

8.国家自然科学基金国际(地区)合作交流项目-中英(NSFC-BC)双边研讨会:理解食物链中抗生素耐药性传播驱动因素(31981330049),2019年,主持。

9.华南农业大学国际科技合作重大项目培育专项:P1噬菌体介导blaCTX-M-27在沙门菌的传播机制研究(2019SCAUGH02),2019-2022年,主持。

10. 国家自然科学基金面上项目:基于微生物信息云平台的养殖场耐头孢菌素类大肠杆菌耐药来源、演变及扩散驱动机制解析(31972734),2020-2024年,主持。

  


代表论著(*通讯作者)


1.Xing-Run Zheng, Jia-Hang Zhu,Jie-Zhang, Ping Cai, Yin-Huan Sun, Man-Xia Chang, Liang-Xing Fang, Jian Sun, Hong-Xia Jiang*. A novel plasmid borne tet(X6) variant co-existing with blaNDM-1 and blaOXA-58 in a chicken Acinetobacter baumannii isolate. J Antimicrob Chemother, Epub 2020 Aug 07, DOI:10.1093/jac/dkaa342

2.Li-Juan Zhang, Xi-Xi Gu, Jie Zhang, Ling Yang, Yue-Wei Lu, Liang-Xing Fang, Hong-Xia Jiang, *. Characterization of a fosA3 carrying IncC-IncN plasmid from a Multidrug-Resistant ST17 Salmonella Indiana Isolate. Frontiers in Microbiology, 2020 July, doi.org/10.3389/fmicb.2020.01582

3.Chuan-Zhen Zhang, Yan Zhang, Xiao-Min Ding, Xiao-Ling Lin, Xin-Lei Lian, Eleftheria Trampari, Nicholas M. Thomson, Huan-Zhong Ding, Mark A. Webber* and Hong-Xia Jiang*. Emergence of ciprofloxacin heteroresistance in foodborne Salmonella enterica serovar Agon. J Antimicrob Chemother. 2020, 75(10):2773-2779.

4.Qiu-Yun Zhao, Pin-Xian Chen, Ling-Yang, Jia-Hang Zhu, Yue-Wei Lu, Liang-Xing Fang, Mark A. Webber and Hong-Xia Jiang*. Transmission of plasmid-borne and chromosomal blaCTX-M-64 among Escherichia coli and Salmonella isolates from food producing animals via ISEcp1-mediated transposition. J Antimicrob Chemother. 2020; 1;75(6):1424-1427. 

5. Jian Sun, Xiao-Ping Liao, Alaric W. D’Souza, Manish Boolchandani, Sheng-Hui Li,Ke Cheng, José Luis Martínez, Liang Li, You-Jun Feng, Liang-Xing Fang, Ting Huang, Jing Xia,Yang Yu, Yu-Feng Zhou, Yong-Xue Sun, Xian-Bo Deng, Zhen-Ling Zeng, Hong-Xia Jiang, Bing-Hu Fang, You-Zhi Tang, Xin-Lei Lian, Rong-Min Zhang, Zhi-Wei Fang, Qiu-Long Yan, Gautam Dantas, Ya-Hong Liu. Environmental remodeling of human gut microbiota and antibiotic resistome in livestock farms. Nature Communications,2020,  DOI: 10.1038/s41467-020-15222-y . 

6. Li-Juan Zhang, Ling Yang, Xi-Xi Gu, Pin-Xian Chen, Jia-Li Fu, Hong-Xia Jiang*. The first isolation of Clostridium difficile RT078/ST11 from pigs in China. PLoS ONE 2019 14(2): e0212965.

7. Chuan-Zhen Zhang, Xiao-Min Ding, Xiao-Ling Lin, Ruan-Yang Sun, Yue-Wei Lu, Run-Mao Cai, Huan-Zhong Ding and Hong-Xia Jiang*. The emergence of chromosomally-located blaCTX-M-55 in Salmonella from foodborne animals in China. Frontiers in microbiology, 2019 June 10; 1268

8. Chuan-Zhen Zhang, Lei Yang, Pin-Xian Chen, Hong-Xia Jiang*. Coordinated expression of AcrAB-TolC  and eight other functional efflux pumps through co-regulation of ramA and marA when any of them are impaired in Salmonella enterica serovar Typhimurium. Microbial Drug Resistance. 2018 Mar;24(2):120-125. doi: 10.1089/mdr.2017.0086. Epub 2017 Jun 26.

9. Chuan-Zhen Zhang, Man-Xia Chang, Lei Yang, Yan-Yan Liu, Pin-Xian Chen, Hong-Xia Jiang*. Up-regulation of AcrEF in quinolone resistance development in E. coli when AcrAB-TolC function is impaired. Microbial Drug Resistance. 2018 Jan/Feb;24(1):18-23. doi: 10.1089/mdr.2016.0207. Epub 2017 May 18. 

10.Chuan-Zhen Zhang, Si-Qi Ren, Man-Xia Chang, Pin-Xian Chen, Hong-Xia Jiang*.Resistance mechanism and fitness of Salmonella Typhimurium and Salmonella Enteritidis during the evolution of resistance under selective pressure with ciprofloxacin in vitro. Sci Rep. 2017 Aug 22;7(1):9113. doi: 10.1038/s41598-017-09151-y.

11. Wen-Hui Zhang, Chuan-Zhen Zhanga, Zhi-Jie Liu, Xi-Xi Gu, Wan Li, Ling Yang, Ya-Hong Liu, Zhen-Ling Zeng, Hong-Xia Jiang*. In Vitro Development of Ciprofloxacin Resistance of Salmonella enterica Serovars Typhimurium, Enteritidis and Indiana isolates from food-animals. Microbial Drug Resistance. 2017 Sep;23(6):687-694. doi: 10.1089/mdr.2016.0119. Epub 2017 Jan 13.

12.Nan Zhang, Xiaomei Ye, Yuzhi Wu, Zilong Huang, Xiaoyan Gu, Qinren Cai, Xiangguang Shen, Hongxia Jiang, Huanzhong Ding. Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin. PLoS One. 2017 Jan 4;12(1):e0169134.

13.Ling Yang, Wan Li, Gui-Ze Jiang, Wen-Hui Zhang, Huan-Zhong Ding, Ya-Hong Liu, Zhen-Ling Zeng* and Hong-Xia Jiang*. Characterization of a P1-like bacteriophage carrying CTX-M-27 in Salmonella spp. resistant to third generation cephalosporins isolated from pork in China. 2017, Scientific Reports, Sci Rep. 2017 Jan 18;7:40710. doi: 10.1038/srep40710.

14.Nan Zhang, Xiaoyan Gu, Xiaomei Ye, Xun Wu, Bingxu Zhang, Longfei Zhang, Xiangguang Shen, Hongxia Jiang and Huanzhong Ding. The PK/PD Interactions of Doxycycline against Mycoplasma gallisepticum. Front Microbiol. 2016 May 4;7:653.

15. Ya-Fei Li, Hong-Xia Jiang, Rong Xiang, Ya-Nan, Zhang, Li-Qing Zhao, Peng Gu, Li-Qiao Wang, Zhen-Ling Zeng. Effects of two efflux pump inhibitors on the drug susceptibility of Riemerella anatipestifer isolates from China. J Integrative Agriculture, 2016,15(4):929-933.

16. Wen-Hui Zhang†, Xiang-Yan Lin†, Liang Xu, Xi-Xi Gu, Ling Yang, Wan Li, Si-Qi Ren, Ya-Hong Liu, Zhen-Ling Zeng* and Hong-Xia Jiang*. CTX-M-27 Producing Salmonella enterica Serotypes Typhimurium and Indiana Are Prevalent among Food-Producing Animals in China. Frontiers in Microbiology, 2016 Mar 31;7:436

17.Xiao-Ping Liao, JingXia, LeiYang, LiangLi, JianSun, Ya-Hong Liu and Hong-Xia Jiang*.. Characterization of CTX-M-14-producing Escherichia coli from food-producing animals. Frontiers in Microbiology, 2015 Oct 15;6:1136

18.Wen-Hui Zhang, Si-Qi Ren, Wan Li, Xi-Xi Gu, Ling Yang, Zhen-Ling Zeng, Ya-Hong Liu, and Hong-Xia Jiang*. High frequency of virulence genes among Escherichia coli with the blaCTX-M genotype from diarrheic piglets in China. Veterinary Microbiology,180 (2015) 260–267。

19.Ling Yang, Lei Yang, Dian-Hong Lü , Wen-Hui Zhang, Si-Qi Ren, Ya-Hong Liu, Zhen-Ling Zeng, Hong-Xia Jiang*. Co-prevalance of PMQR and 16S rRNA methylase genes in clinical Escherichia coli isolates with high diversity of CTX-M from diseased farmed pigeons. Veterinary Microbiology 178 (2015) 238–245.

20.Guo YF, Zhang WH, Ren SQ, Yang L, Lü DH, Zeng ZL, Liu YH, Jiang HX*. IncA/C Plasmid-Mediated Spread of CMY-2 in Multidrug-Resistant Escherichia coli from Food Animals in China. PLoS One. 2014 May 9;9(5):e96738.

21.Jiang HX, Li S, Liu J, Zhang X-H, RenYN, Zhang WH, Zhang JY, Liu YH, Webber MA, D OO, Zeng ZL, Piddock LJV. Multiple transmissible genes encoding fluoroquinolone and third-generation cephalosporin resistance co-located in non-typhoidal Salmonella isolated from food-producing animals in China. Int J Antimicrob Agents. 2014 Mar; 43(3):242-7.

22.Jiang HX, Tang D, Liu YH, Zhang XH, Zeng ZL, Xu L, Hawkey PM.Prevalence and characteristics of β-lactamase and plasmid-mediated quinolone resistance genes in Escherichia coli isolated from farmed fish in China. J Antimicrob Chemother. 2012 Oct;67(10):2350-3.


写给学生的话


  选择了这一研究方向,就要踏踏实实工作,时间长了就会对研究产生兴趣。相信只要努力工作,前途是光明的。