孙永学

孙永学教授 博士生导师

 学科:基础兽医学        
电话/传真:020-85284313/ 85284313         
电子邮件:sunyx@scau.edu.cn         
通讯地址:广州市天河区五山路483号华南农业大学兽医学院 ,510642        
教研室:兽医药理教研室
简介


  孙永学,男,1969年5月出生,湖北省崇阳县人,教授,博士,硕士生与博士生导师,兽医学院副院长。

  兼任国家兽药安全评价(环境评估)实验室(华南农大)副主任、中国畜牧兽医学会兽医药理毒理学分会与动物毒物学分会理事、中国实验动物学会水生实验动物分会委员、农业部畜产品质量安全风险评估实验室(青岛)技术委员会委员、农业农村部第七届兽药评审委员会专家等。

  1995年7月,毕业于华南农业大学动物医学系获兽医药理学与毒理学方向硕士学位留校任教,2003年获华南农业大学基础兽医学专业博士学位。2012年晋升为教授,2017年评聘为博士生导师。

主要从事兽医药理学与毒理学、兽药及添加剂的分子生态毒理学及其风险评估、噬菌体相关研究(耐药性传播与治疗)。近年来主要开展了有机胂添加剂、CuSO4与ZnO添加剂、氟喹诺酮类药物、氟苯尼考、粘菌素等的分子生态毒理学研究与早期预警及其风险评估;畜禽产品中有害物质(T-2、F-2等真菌毒素)组织消长规律与残留路径等系列研究,在生态毒理学研究方面目前在国内同行属于研究最早并处于国内领先水平。

  已主持12项和参与10多项各级科研课题,其中包括主持国家自然科学基金2项,国际合作科研项目、广东省自然科学基金重点项目及自由申请项目、广东省科技计划项目、公益性行业(农业)专项课题等各1项以及多项农业部专项课题等,主要参与国家自然科学基金重点项目、国家“十一五”支撑计划、国家“973”计划项目、十三五国家重大专项等各类课题10多项。

  已发表论文60多篇,SCI收录论文25篇,其中第一或通讯作者21篇。获授权专利2项,主编全国执业兽医考试参考书五部、副主编《动物中毒病》教材一部、参译兽医药理学译著《兽医药理学与治疗学》(第九版)、参著《兽药手册》和参编全国十二五统编教材《动物毒理学》各一部。

  获广东省科学技术奖一等奖2项(2006、2015),全国农牧渔业丰收奖三等奖、广东省茂名市科学技术奖二等奖等各1项。获国家二类新兽药证书1项,授权专利5项。


学历及培训经历


1998年07月-2003年06月  华南农业大学兽医学院    博士研究生

1992年07月-1995年06月  华南农业大学动物医学系  硕士研究生

1987年07月-1992年06月  南京农业大学兽医系      本科生


工作经历


1995年07月起历任华南农业大学兽医学院讲师(1998-2003)、副教授(2004-2012)、硕士研究生导师(2004)、教授(2013-)、博士研究生导师(2017);

华南农业大学兽医学院任基础兽医系系主任(2007.9-2011.10);

华南农业大学兽医学院教工第一党支部书记(2007.9-2015.8);

国家兽药安全评价(环境评估)实验室(华南农大)副主任(2008-今);

兽医学院副院长(2015.1-今)


研究领域


•  兽医药理学与毒理学、兽药及添加剂的生态毒理学

•  噬菌体生态学与定向诱导 


承担科研项目情况


• 国家自然科学基金项目:抗生素胁迫下环境微生物互作及反硝化分子响应的宏基因组学分析(31772803),2018-2021,主持

• 国家自然科学基金项目:有机胂添加剂对环境污染胁迫的分子诊断与早期预警研究(31172368),2012-2015,主持

• 广东省自然科学基金重点项目:抗菌药残留环境胁迫下微生物群落多样性与氮素循环反硝化分子响应特征

研究(2016A030311029),2016-2019,主持

• 广东省自然科学基金项目:有机砷添加剂对环境污染胁迫的分子诊断研究(S2011010001090),2011-2014,主持

• 公益性行业科研专项:动物卫生风险分析关键技术与应用研究(200903055)子课题,2009-2013,主持

• 广东省科技计划项目:有机胂添加剂在畜禽饲后的生态毒性与风险评估研究,2009-2012,主持

• 国际合作项目(美国):“Evaluation of the Effectiveness of triptorelin gel to synchronize the time of insemination in weaned sows”,2014-2015,主持


代表论著(*通讯作者)


1. Mei Wang,Wenguang Xiong,Yong Zou,Manxia Lin,Qin Zhou,Xiying Xie ,Yongxue Sun.Evaluating the net effect of sulfadimidine on nitrogen removal in an aquatic microcosm environment. Environmental Pollution 248 (2019) 1010-1019.

2. Zou, Yong, Manxia Lin, Wenguang Xiong, Mei Wang, Jiaxuan Zhang, Mianzhi Wang, and Yongxue Sun. Metagenomic insights into the effect of oxytetracycline on microbial structures, functions and functional genes in sediment denitrification. Ecotoxicology and Environmental Safety,2018. 161:85-91.

3. M. Wang, S.-Y. Chen, J.-X. Zhang,X.-X. He, W.-G. Xiong and Y.-X. Sun. Variations of antibiotic resistance profiles in chickens during administration of amoxicillin, chlortetracycline and florfenicol. Journal of Applied Microbiology,2018,125, 1692-1701.

4. Wang, Mianzhi, Peng Liu, Wenguang Xiong, Qin Zhou, Junyi Wangxiao, Zhenling Zeng, and Yongxue Sun. Fate of potential indicator antimicrobial resistance genes (ARGs) and bacterial community diversity in simulated manure-soil microcosms. Ecotoxicology and Environmental Safety. 2018,147: 817-823.

5. Peng Liu, Mianzhi Wang, Weixin Zhong, Qin Zhou, Xiying Xie, Junyi Wangxiao, Yongxue Sun. Stress-responsive genes (hsp70 and mt) and genotoxicity elicited by roxarsone exposure in Carassius auratus. Environmental Toxicology and Pharmacology,2018,62,132-139.

6. Qin Zhou, Mianzhi Wang, Xiaoxia Zhong, Peng Liu, Xiying Xie, Junyi Wangxiao, Yongxue Sun. Dissemination of resistance genes in duck/fish polyculture ponds in Guangdong Province: correlations between Cu and Zn and antibiotic resistance genes. Environmental Science and Pollution Research, 2019. https://doi.org/10.1007/s11356-018-04065-2

7. Mianzhi Wang, Wenguang Xiong, Peng Liu, Xiying Xie,Jiaxiong Zeng, Yongxue Sun, Zhenling Zeng. Metagenomic insights into the contribution of phages to antibiotic resistance in water samples related to swine feedlot wastewater treatment. Frontiers in Microbiology, 2018, doi: 10.3389/fmicb.2018.02474

8. Wang, Mianzhi, Peng Liu, Qin Zhou, Wanyu Tao, Yongxue Sun, and Zhenling Zeng. Estimating the contribution of bacteriophage to the dissemination of antibiotic resistance genes in pig feces.Environmental Pollution. 2018, 238:291-298.

9. Wenguang Xiong, Mei Wang, Jinjun Dai, Yongxue Sun, Zhenling Zeng. Application of manure containing tetracyclines slowed down the dissipation of tet resistance genes and caused changes in the composition of soil bacteria. Ecotoxicology and Environmental Safety 2018,147:455-460

10. Wenguang Xiong, Yulin Wang, Yongxue Sun, Liping Ma, Qinglin Zeng, Xiaotao Jiang, Andong Li,Zhenling Zeng and Tong Zhang. Antibiotic-mediated changes in the fecal microbiome of broiler chickens define the incidence of antibiotic resistance genes. Microbiome,2018,6:34

11. Mianzhi Wang, Yongxue Sun, Peng Liu, Jinsun; Qin Zhou; Wenguang Xiong, Zhenling Zeng. Fate of antimicrobial resistance genes in response to application of poultry and swine manure in simulated manure-soil microcosms and manure-pond microcosms. Environmental Science and Pollution Research. 2017, 24(26): 20949-20958.

12. Mianzhi Wang, Jinsun, Wenguang,Xiong, Zhenling Zeng, Yongxue Sun. Presence and distribution of Macrolides-Lincosamide-   Streptogramin resistance genes and potential indicator ARGs in the university ponds in Guangzhou, China. Environmental Science and Pollution Research, 2016, 23(22):22937-22946.

13. Xiong, W., Zeng, Z., Zhang, Y., Ding, X. , Sun, Y. Fate of metal resistance genes in arable soil after manure application in a microcosm study. Ecotoxicology and environmental safety , 2015,113: 59-63.

14. Ruizi Guo, Xueyao Ding, Wenguang Xiong, Xiaoxia Zhong, Wenfei Liang, Shangji Gao, Mei Hong, Yongxue Sun. Earthworms as agents for ecotoxicity in roxarsone-contaminated soil ecosystem: a modeling study of ultrastructure and proteomics. Environ Sci Pollut Res,2015, 22(16):12435–12449.

15. Y. X. SUN, X. YAO, S. N. SHI, G. J. ZHANG, L. X. XU, Y. J. LIU, B. H. FANG. Toxicokinetics of T-2 toxin and its major metabolites in broiler chickens after intravenous and oral administration. J. Vet. Pharmacol. Therap,2015,38(1):80-85.

16. Xiong, W. , Sun, Y. Ding, X., Wang, M. and Zeng, Z. Selective pressure of antibiotics on ARGs and bacterial communities in manure-polluted freshwater-sediment microcosms. Frontiers in Microbiology. 2015, 6, 194.

17. Xiong, W., Sun, Y., Zhang, T., Ding, X., Li, Y., Wang, M. and Zeng, Z. Antibiotics, Antibiotic Resistance Genes, and Bacterial Community Composition in Fresh Water Aquaculture Environment in China. Microbial Ecology, 2015, 70(2): 425-432.

18. Ruizi Guo, Xueyao Ding, Xiaoxia Zhong, Shangji Gao,Yongxue Sun. Molecular and ultrastructural insights into the earthworm Eisenia fetida of the assessment of cotoxicity during colistin exposure. Environ Sci Pollut Res. 2014, 21:13405-13411.

19. Xiong, W, Ding, X, Zhang, Y and Sun, Y. Ecotoxicological effects of a veterinary food additive, copper sulphate, on antioxidant enzymes and mRNA expression in earthworms. Environmental toxicology and pharmacology, 2014, 37(1), 134-140.  

20. Xiong, W.†, Sun, Y. †, Ding, X., Zhang, Y. and Zeng, Z. Antibiotic resistance genes occurrence and bacterial community composition in the Liuxi River. Frontiers in Environmental Science. 2014, 2, 61.

21. Yongxue Sun1, Guijun Zhang1, Haiyan Zhao, Jianlong Zheng, Fangyuan Hu, Binghu Fang. Liquid chromatography–tandem mass spectrometry method fortoxicokinetics, tissue distribution, and excretion studies of T-2 toxinand its major metabolites in pigs. Journal of Chromatography B, 2014,958:75–82.

22.Yongxue Sun, Zhenqing Dai, Wenguang Xiong, Xuelian Luo, Mengjia Zou. Fate of Florfenicol in a Simulated Aquatic Ecosystem and Effects on Sediment Microflora. Water Environment Research, 2012, 84(8): 2054-2059.


写给学生的话


  先做人后做事;凡在科研道路上取得成就者,不一定是最聪明的人,但必定是勤奋、肯吃苦、耐得住寂寞的人!