Education and Professional Experience

Dec. 2013 - present, Associate professor, Head of Teaching and Research Section of Veterinary Microbiology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

Sept. 2018 – Sept. 2019, Visiting Scholar, Gene Therapy Center, University of Massachusetts Medical School, MA, U.S.

July 2009 - Dec. 2013, Lecturer, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

Sept. 2004 - July 2009, Ph.D. in Food Safety Biology, School of Life Science, Sun Yat-Sen University, Guangzhou, China.

Sept. 2000 - July 2004, B.S. in Biotechnology, College of Science, Shantou University, Shantou, China

Current Research Topics

Interplay between rabies virus and type I IFN signaling pathway in the central nervous system

The application of reverse genetics technology in the study of rabies virus  pathogenesis and for the development of novel rabies vaccines

Development of oral vaccine vectors for infectious diseases of animals

Projects 

2012 - 2014, project director for the National Natural Science Foundation of China, Characteristic difference of pathogenic and attenuated rabies virus strain infection in primary neurons (No. 31101842). 

2014 - 2017, project director for Science and Technology Planning Project of Guangdong Province, Application of matrix gene-deleted rabies virus vector in the development of novel animal vaccine and detection of virus-neutralizing antibody (No. 2014A020214006).

2015 - 2018, project director for Science and Technology Planning Project of Guangdong Province, Rabies virus with gene deletion as an oral vaccine against animal rabies (2015A020209100).

2014 - 2017, project director for Foundation for Fostering of Outstanding Young Teachers in Higher Education Institutions of Guangdong Province (No. yq2014029).

Publications (*corresponding author, #co-first author)

Luo J, Zhang B, Wu Y, Tian Q, Zhao J, Lyu Z, Zhang Q, Mei M, Luo Y*, Guo X*. Expression of interleukin-6 by a recombinant rabies virus enhances its immunogenicity as a potential vaccine. Vaccine. 2017 Feb 7;35(6):938-944. 

Zhang D, He F, Bi S, Guo H, Zhang B, Wu F, Liang J, Yang Y, Tian Q, Ju C, Fan H, Chen J, Guo X*, Luo Y*. Genome-Wide Transcriptional Profiling Reveals Two Distinct Outcomes in Central Nervous System Infections of Rabies Virus. Front Microbiol. 2016 May 19;7:751.

Yang Y, Liu W, Yan G, Luo Y*, Zhao J, Yang X, Mei M, Wu X, Guo X*. iTRAQ protein profile analysis of neuroblastoma (NA) cells infected with the rabies viruses rHep-Flury and Hep-dG. Front Microbiol. 2015 Jul 7;6:691. 

Wang Y, Tian Q, Xu X, Yang X, Luo J, Mo W, Peng J, Niu X, Luo Y, Guo X. Recombinant rabies virus expressing IFNα1 enhanced immune responses resulting in its attenuation and stronger immunogenicity. Virology. 2014 Nov;468-470:621-30. 

Pei J, Zhao M, Ye Z, Gou H, Wang J, Yi L, Dong X, Liu W, Luo Y, Liao M, Chen J. Autophagy enhances the replication of classical swine fever virus in vitro. Autophagy. 2014 Jan;10(1):93-110. 

Luo Y, Zhang Y, Liu X, Yang Y, Yang X, Zheng Z, Deng X, Wu X, Guo X. Characterization of a wild rabies virus isolate of porcine origin in China. Infect Genet Evol. 2013 Jul;17:147-52. 

Shuang F, Luo Y, Xiong XP, Weng S, Li Y, He J, Dong C. Virions proteins of an RSIV-type megalocytivirus from spotted knifejaw Oplegnathus punctatus (SKIV-ZJ07). Virology. 2013 Mar 15;437(2):89-99. 

Dong C, Xiong X, Luo Y, Weng S, Wang Q, He J. Efficacy of a formalin-killed cell vaccine against infectious spleen and kidney necrosis virus (ISKNV) and immunoproteomic analysis of its major immunogenic proteins. Vet Microbiol. 2013 Mar 23;162(2-4):419-28. 

Ye Y, Yan G, Luo Y, Tong T, Liu X, Xin C, Liao M, Fan H. Quantitative proteomics by amino acid labeling in foot-and-mouth disease virus (FMDV)-infected cells. J Proteome Res. 2013 Jan 4;12(1):363-77. 

Luo Y, Zhang Y, Liu X, Yang Y, Yang X, Zhang D, Deng X, Wu X, Guo X. Complete genome sequence of a highly virulent rabies virus isolated from a rabid pig in south China. J Virol. 2012 Nov;86(22):12454-5. 

Luo Y, Zhang J, Deng X, Ye Y, Liao M, Fan H. Complete genome sequence of a highly prevalent isolate of porcine epidemic diarrhea virus in South China. J Virol. 2012 Sep;86(17):9551. 

Fan H#, Ye Y#, Luo Y#, Tong T, Yan G, Liao M. Quantitative proteomics using stable isotope labeling with amino acids in cell culture reveals protein and pathway regulation in porcine circovirus type 2 infected PK-15 cells. J Proteome Res. 2012 Feb 3;11(2):995-1008. 

Guo CJ, Liu D, Wu YY, Yang XB, Yang LS, Mi S, Huang YX, Luo YW, Jia KT, Liu ZY, Chen WJ, Weng SP, Yu XQ, He JG. Entry of tiger frog virus (an Iridovirus) into HepG2 cells via a pH-dependent, atypical, caveola-mediated endocytosis pathway. J Virol. 2011 Jul;85(13):6416-26.

Dong CF, Xiong XP, Shuang F, Weng SP, Zhang J, Zhang Y, Luo YW, He JG.  Global landscape of structural proteins of infectious spleen and kidney necrosis virus. J Virol. 2011 Mar;85(6):2869-77.

Dong C, Weng S, Luo Y, Huang M, Ai H, Yin Z, He J. A new marine megalocytivirus from spotted knifejaw, Oplegnathus punctatus, and its pathogenicity to freshwater mandarinfish, Siniperca chuatsi. Virus Res. 2010 Jan;147(1):98-106.

Luo Y, Weng S, Wang Q, Shi X, Dong C, Lu Q, Yu X, He J. Tiger frog virus can infect zebrafish cells for studying up- or down-regulated genes by proteomics approach. Virus Res. 2009 Sep;144(1-2):171-9. 

Wang Q#, Luo Y#, Xie J, Dong C, Weng S, Ai H, Lü L, Yang X, Yu X, He J. Identification of two novel membrane proteins from the Tiger frog virus (TFV). Virus Res. 2008 Sep;136(1-2):35-42.