Jian-Hua Liu

Jian-Hua Liu

 Discipline:	Basic Veterinary Medicine
Tel\Fax:	13535406446
E-Mail:	jhliu@scau.edu.cn
Address:	College of Veterinary Medicine, South China Agricultural University, 510642, PR China
Additional Information:	Department of Basic Veterinary Medicine 

Resume:

Jian-Hua Liu,Female,Born in October, 1973, Jiangxi province, Ph.D. in Veterinary Medicine, Professor, doctoral supervisor, winner of the National Science Fund for Distinguished Young Scholars, the member of National Expert Committee for Control of Veterinary Drug Residue and Antimicrobial Resistance, Deputy Director of National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria. 

Prof. Liu received her bachelor's degree and Ph.D Degree in Veterinary Medicine at China Agricultural University in 2001, and furthered her postdoctoral research in the college of Veterinary Medicine at South China Agricultural University during 2001-2003. She was appointed Associate Professor of Veterinary Medicine at South China Agricultural University in 2003 and was promoted to professor in 2013.

Her current research focuses on the emerging and transfer mechanisms of antimicrobial resistance in Enterobacteriaceae, and the evolution of antimicrobial resistance and resistance plasmids. She discovered for the first time the emergence of plasmid-mediated colistin resistance gene, mcr-1. She has published over 40 peer- reviewed papers which were published in top journals, incl. Lancet Infect Dis., and received a total citation of more than 2500 times. Two of the published papers have been recommended to “F1000 prime” and two papers have been selected as ESI highly cited papers. Prof. Liu was reward with National Science Fund for Distinguished Young Scholars (2016) and also serves as review editor for Frontier Microbiology. 

Education and Training Program: 

July, 1996- June, 2001: Ph.D., College of Veterinary Medicine, China Agricultural University, Beijing, China

September, 1991- June, 1996: B.S, College of Veterinary Medicine, China Agricultural University, Beijing, China

Working Experience: 

July,2013- present: Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China 

February, 2014- August, 2014: Visiting Fellow at the Hong Kong Polytechnic University, Hong Kong, China

July, 2003- July, 2013: Associate Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China 

July, 2001- July, 2003: Post-doctoral fellow, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

Research Interests:

Evolution of antimicrobial resistance and resistance plasmids

Antimicrobial resistance mechanisms and transfer mechanisms of antimicrobial resistance genes

Safety evaluation of the use of antimicrobial agents in food animals

Antimicrobial Resistance Monitoring and Antimicrobial susceptibility testing

Grants: 

Funding Source: National Natural Science Foundation of China, 2019-2023 

Title: Mechanisms of the adaptive evolution of colistin resistance plasmids and hosts.

Funding Source: National Science Fund for Excellent Young Scholars, 2017-2021

Title: Veterinary pharmacology

Funding Source: National Natural Science Foundation of China, 2013-2016 

Title: Investigation of the influence of oqxAB to quinolone resistance and the adaptability of plasmids with oqxAB.

Funding Source: Foundation For High-level Talents In Higher Education of Guangdong, China, 2013-2015

Title: Investigation of the co-transfer mechanism of blaCTX-M and fosfomycin resistance gene fosA3.

Funding Source: National Training Program For the Major Research Plan of China, 2013-2017

Title: Molecular mechanisms of antimicrobial resistance in pathogens of livestock.

Publications:

1.Wang J, Zeng ZL, Huang XY, Ma ZB, Guo ZW, Lv LC, Xia YB, Zeng L, Song QH, Liu JH*. Evolution and Comparative Genomics of F33:A-:B- Plasmids Carrying blaCTX-M-55 or blaCTX-M-65 in Escherichia coli and Klebsiella pneumoniae Isolated from Animals, Food Products, and Humans in China. mSphere. 2018 Jul 18;3(4). pii: e00137-18.

2.Liu Y, Liu JH*. Monitoring Colistin Resistance in Food Animals, An Urgent Threat. Expert Rev Anti Infect Ther. 2018 Jun;16(6):443-446.

3.Lv L, Zeng Z, Song Q, Cao Y, Wang J, Li W, Wen Q, Zhang Q, Wan M, Yang J, Liu JH*. Emergence of XDR Escherichia coli carrying both blaNDM and mcr-1 genes in chickens at slaughter and the characterization of two novel blaNDM-bearing plasmids. J Antimicrob Chemother. 2018 May 22. doi: 10.1093/jac/dky176.

4.Wu R, Yi LX, Yu LF, Wang J, Liu Y, Chen X, Lv L, Yang J, Liu JH*. Fitness Advantage of mcr-1-Bearing IncI2 and IncX4 Plasmids in Vitro. Front Microbiol. 2018 Feb 27;9:331.

5.Lv L, Cao Y, Yu P, Huang R, Wang J, Wen Q, Zhi C, Zhang Q, Liu JH*. Detection of mcr-1 gene among Escherichia coli isolates from farmed fish and characterization of mcr-1-bearing IncP plasmids. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02378-17. doi: 10.1128/AAC.02378-17. 

6.Li W, Liu JH, Zhang XF, Wang J, Ma ZB, Chen L, Zeng ZL. Emergence of methicillin-resistant Staphylococcus aureus ST398 in pigs in China. Int J Antimicrob Agents. 2018 Feb;51(2):275-276. doi: 10.1016/j.ijantimicag.2017.10.013.

7.Wang J, Yao X, Luo J, Lv L, Zeng Z, Liu JH*. Emergence of Escherichia coli coproducing NDM-1 and KPC-2 carbapenemases from a retail vegetable, China. J Antimicrob Chemother, 2018 Jan 1;73(1):252-254.

8.Wang J, Zhi CP, Chen XJ, Guo ZW, Liu WL, Luo J, Huang XY, Zeng L, Huang JW, Xia YB, Yi MY, Huang T, Zeng ZL, Liu JH*. Characterization of <i>oqxAB</i> in <i>Escherichia coli</i> Isolates from Animals, Retail Meat, and Human Patients in Guangzhou, China. Front Microbiol. 2017 Oct 13;8:1982. doi: 10.3389/fmicb.2017.01982.

9.Luo J, Yao X, Lv L, Doi Y, Huang X, Huang S, Liu JH*. Emergence of mcr-1 in Raoultella ornithinolytica and Escherichia coli from retail vegetables, China. Antimicrob Agents Chemother. 2017 Jul 24. 2017 Sep 22;61(10). pii: e01139-17. doi: 10.1128/AAC.01139-17.

10.Huang X, Yu L, Chen X, Zhi C, Yao X, Liu Y, Wu S, Guo Z, Yi L, Zeng Z, Liu JH*. High Prevalence of Colistin Resistance and <i>mcr-1</i> Gene in <i>Escherichia coli</i> Isolated from Food Animals in China. Front Microbiol. 2017 Apr 4;8:562. 

11.He D, Liu L, Guo B, Wu S, Chen X, Wang J, Zeng Z, Liu JH*. Chromosomal location of the fosA3 and bla<sub>CTX-M</sub> genes in Proteus mirabilis and clonal spread of Escherichia coli ST117 carrying fosA3-positive IncHI2/ST3 or F2:A-:B- plasmids in a chicken farm. Int J Antimicrob Agents, 2017, 49(4):443-448.

12.Wang J, Guo ZW, Zhi CP, Yang T, Zhao JJ, Chen XJ, Zeng L, Lv LC, Zeng ZL, Liu JH*. Impact of plasmid-borne oqxAB on the development of fluoroquinolone resistance and bacterial fitness in Escherichia coli. J Antimicrob Chemother, 2017, 72 (5): 1293-1302 

13.Yi L, Liu Y, Wu R, Liang Z, Liu JH*. Research progress on the plasmid-mediated colistin resistance gene mcr-1. Yi Chuan. 2017 Feb 20;39(2):110-126. doi: 10.16288/j.yczz.16-331.

14.Wang J, Ma ZB, Zeng ZL, Yang XW, Huang Y, Liu JH*. The role of wildlife (wild birds) in the global transmission of antimicrobial resistance genes. Zool Res. 2017 Mar 18;38(2):55-80.

15.Yi L, Wang J, Gao Y, Liu YY, Doi Y, Wu R, Zeng Z, Liang Z, Liu JH*. mcr-1 Producing Salmonella enterica Serovar Typhimurium Sequence Type 34 in Pigs, China. Emerg Infect Dis, 2017, 23(2):291-295. 

16.He D, Chiou J, Zeng Z, Chan EW, Liu JH*, Chen S*. Comparative characterization of CTX-M-64 and CTX-M-14: insights into the structure and catalytic activity of the CTX-M class of enzymes. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6084-90..

17.Zhi C, Lv L, Yu LF, Doi Y, Liu JH*. Dissemination of the mcr-1 colistin resistance gene. Lancet Infect Dis. 2016,16(3):292-3. 

18.Yao X, Doi Y, Zeng L, Lv L, Liu JH*. Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1. Lancet Infect Dis. 2016, 16(3):288-9. 

19.Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Doi Y, Tian G, Dong B, Huang X, Yu LF, Gu D, Ren H, Chen X, Lv L, He D, Zhou H, Liang Z, Liu JH*, Shen J*. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016; 16(2): 161-8. 

20.He D, Chiou J, Zeng Z, Liu L, Chen X, Zeng L, Chan EW, Liu JH*, Chen S*. Residues Distal to the Active Site Contribute to Enhanced Catalytic Activity of Variant and Hybrid β-Lactamases Derived from CTX-M-14 and CTX-M-15. Antimicrob Agents Chemother. 2015, 59(10):5976-83. 

21.Liu L, He D, Lv L, Liu W, Chen X, Zeng Z, Partridge SR*, Liu JH*. blaCTX-M-1/9/1 Hybrid Genes May Have Been Generated from blaCTX-M-15 on an IncI2 Plasmid. Antimicrob Agents Chemother. 2015, 59(8):4464-70. 

22.Wang J, Lin DC, Guo XM, Wei HK, Liu XQ, Chen XJ, Guo JY, Zeng ZL*, Liu JH*. Distribution of the Multidrug Resistance Gene cfr in Staphylococcus Isolates from Pigs, Workers, and the Environment of a Hog Market and a Slaughterhouse in Guangzhou, China. Foodborne Pathog Dis. 2015, 12(7):598-605. 

23.Yang X, Liu W, Liu Y, Wang J, Lv L, Chen X, He D, Yang T, Hou J, Tan Y, Xing L, Zeng Z, Liu JH*. F33: A-: B-, IncHI2/ST3, and IncI1/ST71 plasmids drive the dissemination of fosA3 and bla CTX-M-55/-14/-65 in Escherichia coli from chickens in China. Front Microbiol. 2014, 5:688. 

24.Chen X, He L, Li Y, Zeng Z, Deng Y, Liu Y*, Liu JH*. Complete sequence of a F2:A-:B- plasmid pHN3A11 carrying rmtB and qepA, and its dissemination in China. Vet Microbiol. 2014, 174(1-2):267-71. 

25.Yang T, Zeng Z, Rao L, Chen X, He D, Lv L, Wang J, Zeng L, Feng M, Liu JH*. The association between occurrence of plasmid-mediated quinolone resistance and ciprofloxacin resistance in Escherichia coli isolates of different origins. Vet Microbiol. 2014, 170(1-2):89-96.

26.Zeng ZL, Wei HK, Wang J, Lin DC, Liu XQ, Liu JH*. High prevalence of Cfr-producing Staphylococcus species in retail meat in Guangzhou, China. BMC Microbiol. 2014, 14:151.

27.Rao L, Lv L, Zeng Z, Chen S, He D, Chen X, Wu C, Wang Y, Yang T, Wu P, Liu Y, Liu JH*. Increasing prevalence of extended-spectrum cephalosporin-resistant Escherichia coli in food animals and the diversity of CTX-M genotypes during 2003-2012. Vet Microbiol. 2014, 172(3-4):534-41.

28.He D, Partridge SR, Shen J, Zeng Z, Liu L, Rao L, Lv L, Liu JH*. CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China. Antimicrob Agents Chemother. 2013, 57(8):4068-71.

29.Lv L, Partridge SR, He L, Zeng Z, He D, Ye J, Liu JH*. Genetic characterization of IncI2 plasmids carrying blaCTX-M-55 spreading in both pets and food animals in China. Antimicrob Agents Chemother. 2013, 57(6):2824-7. 

30.Deng YT, Zeng ZL, Tian W, Yang T, Liu JH*. Prevalence and characteristics of rmtB and qepA in Escherichia coli isolated from diseased animals in China. Front Microbiol. 2013, 4:198. 

31.Hou J, Yang X, Zeng Z, Lv L, Yang T, Lin D, Liu JH*. Detection of the plasmid-encoded fosfomycin resistance gene fosA3 in Escherichia coli of food-animal origin. J Antimicrob Chemother. 2013, 68(4):766-70. 

32.He L, Partridge SR, Yang X, Hou J, Deng Y, Yao Q, Zeng Z, Chen Z, Liu JH*. Complete nucleotide sequence of pHN7A8, an F33:A-:B- type epidemic plasmid carrying blaCTX-M-65, fosA3 and rmtB from China. J Antimicrob Chemother. 2013, 68(1):46-50. 

33.Feng Y, Tian W, Lin D, Luo Q, Zhou Y, Yang T, Deng Y, Liu YH*, Liu JH*. Prevalence and characterization of methicillin-resistant Staphylococcus pseudintermedius in pets from South China. Vet Microbiol. 2012, 160(3-4):517-24. 

34.Ma J, Liu JH*, Lv L, Zong Z, Sun Y, Zheng H, Chen Z, Zeng ZL*. Characterization of extended-spectrum β-lactamase genes found among Escherichia coli isolates from duck and environmental samples obtained on a duck farm. Appl Environ Microbiol. 2012, 78(10):3668-73.

35.Zheng H, Zeng Z, Chen S, Liu Y, Yao Q, Deng Y, Chen X, Lv L, Zhuo C, Chen Z, Liu JH*. Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in China. Int J Antimicrob Agents. 2012, 39(4):305-10.

36.Hou J, Huang X, Deng Y, He L, Yang T, Zeng Z, Chen Z, Liu JH*. Dissemination of the fosfomycin resistance gene fosA3 with CTX-M β-lactamase genes and rmtB carried on IncFII plasmids among Escherichia coli isolates from pets in China. Antimicrob Agents Chemother. 2012, 56(4):2135-8. 

37.Sun N, Liu JH*, Yang F, Lin DC, Li GH, Chen ZL, Zeng ZL*. Molecular characterization of the antimicrobial resistance of Riemerella anatipestifer isolated from ducks. Vet Microbiol. 2012, 158(3-4):376-83. 

38.Yao Q, Zeng Z, Hou J, Deng Y, He L, Tian W, Zheng H, Chen Z, Liu JH*. Dissemination of the rmtB gene carried on IncF and IncN plasmids among Enterobacteriaceae in a pig farm and its environment. J Antimicrob Chemother. 2011, 66(11):2475-9. 

39.Deng Y, He L, Chen S, Zheng H, Zeng Z, Liu Y, Sun Y, Ma J, Chen Z, Liu JH*. F33:A-:B- and F2:A-:B- plasmids mediate dissemination of rmtB-blaCTX-M-9 group genes and rmtB-qepA in Enterobacteriaceae isolates from pets in China. Antim icrob Agents Chemother. 2011, 55(10):4926-9.

40.Deng Y, Zeng Z, Chen S, He L, Liu Y, Wu C, Chen Z, Yao Q, Hou J, Yang T, Liu JH*. Dissemination of IncFII plasmids carrying rmtB and qepA in Escherichia coli from pigs, farm workers and the environment. Clin Microbiol Infect. 2011, 17(11):1740-5. 

41.Sun Y, Zeng Z, Chen S, Ma J, He L, Liu Y, Deng Y, Lei T, Zhao J, Liu JH*. High prevalence of bla(CTX-M) extended-spectrum β-lactamase genes in Escherichia coli isolates from pets and emergence of CTX-M-64 in China. Clin Microbiol Infect. 2010, 16(9):1475-81. 

42.Zhao J, Chen Z, Chen S, Deng Y, Liu Y, Tian W, Huang X, Wu C, Sun Y, Sun Y, Zeng Z, Liu JH*. Prevalence and dissemination of oqxAB in Escherichia coli isolates from animals, farmworkers, and the environment. Antimicrob Agents Chemother. 2010, 54(10):4219-24. 

43.Lei T, Tian W, He L, Huang XH, Sun YX, Deng YT, Sun Y, Lv DH, Wu CM, Huang LZ, Shen JZ, Liu JH*. Antimicrobial resistance in Escherichia coli isolates from food animals, animal food products and companion animals in China. Vet Microbiol. 2010, 146(1-2):85-9. 

44.Ma J, Zeng Z, Chen Z, Xu X, Wang X, Deng Y, Lü D, Huang L, Zhang Y, Liu JH*, Wang M*. High prevalence of plasmid-mediated quinolone resistance determinants qnr, aac(6')-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrob Agents Chemother. 2009, 53(2):519-24. 

45.Liu JH, Deng YT, Zeng ZL, Gao JH, Chen L, Arakawa Y, Chen ZL. Coprevalence of plasmid-mediated quinolone resistance determinants QepA, Qnr, and AAC(6')-Ib-cr among 16S rRNA methylase RmtB-producing Escherichia coli isolates from pigs. Antimicrob Agents Chemother. 2008, 52(8):2992-3. 

46.Chen L, Chen ZL, Liu JH*, Zeng ZL, Ma JY, Jiang HX. Emergence of RmtB methylase-producing Escherichia coli and Enterobacter cloacae isolates from pigs  in China. J Antimicrob Chemother. 2007 , 59(5):880-5. 

47.Liu JH, Wei SY, Ma JY, Zeng ZL, Lü DH, Yang GX, Chen ZL. Detection and characterisation of CTX-M and CMY-2 beta-lactamases among Escherichia coli isolates from farm animals in Guangdong Province of China. Int J Antimicrob Agents. 2007, 29(5):576-81. 

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