华南农业大学兽医学院

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孙坚

姓名:孙坚

学         科:基础兽医学

电话/传真:020-85285507/15828215217  

电子邮件:jiansun@scau.edu.cn 

通讯地址:广州市天河区五山路483号华南农业大学兽医学院 510642

更多信息:药理教研室   个人主页   English

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个人详细情况

孙坚,华南农业大学,兽医学院,青年教授

近年来,细菌耐药性问题十分突出,已经成为威胁人类健康和公共卫生的重大隐患。围绕相关的研究热点,主要从事动物源细菌耐药性的监测、耐药及传播机制研究、耐药性防控技术等研究。共发表SCI论文57篇,其中以第一作者/通信作者在《Nature Microbiology》、《Journal of Antimicrobial Chemotherapy》和《Antimicrobial Agents and Chemotherapy》等国际著名杂志发表了SCI论文30篇(二区以上24篇);获2015年广东省科学技术奖一等奖1项(排名第14),并入选2016年度广州市“珠江科技新星”;申请国家发明专利2 项,获软件著作权1项;

教育经历

1.2007/92012/6,华南农业大学,基础兽医学,博士,导师:刘雅红

2.2003/92007/6,广西大学,动物医学,学士,导师:吴文德

工作经历

1.2016/12-至今, 华南农业大学,兽医学院,青年教授

2.2015/10-至今,华南农业大学,兽医学院,副教授

3.2013/10-2015/9,华南农业大学,兽医学院,讲师

4.2012/7-2013/7,美国爱荷华州立大学,博士后,合作导师:张启敬

主持或参加科研项目:

(1)国家自然科学基金青年基金项目,31402247,动物源大肠杆菌HI2型多重耐药质粒流行特征及亚抑菌浓度抗生素对其传播的影响,2015/01-2017/12,25万元,在研,主持

(2)广州市珠江新星专项,IncHI2型质粒促进大肠杆菌生物被膜形成机制研究,2016/01-2018/12,30万元,在研,主持

(3)国家自然科学基金重点国际(地区)合作研究项目,31520103918,质粒协助沙门菌的适应性及其机制研究,2016/01-2020/12,300万元,在研,参加

代表论著:

(1) Sun, Jian(#)Yang, Run-Shi(#)Zhang, QijingFeng, YoujunFang, Liang-XingXia, JingLi, LiangLv, Xiao-YueDuan, Jia-HongLiao, Xiao-Ping (*)Liu, Ya-Hong(*)Co-transfer of blaNDM-5 and mcr-1 by an IncX3-X4 hybrid

plasmid in Escherichia coli.Nat Microbiol2016.9.26116176~16176

(2) Sun, Jian(#)Fang, Liang-Xin(#)Wu, ZuoweiDeng, HuiYang, Rui-ShiLi, Xing-PingLi, Shu-MinLiao-Xiao-PingFeng, Youjun(*)Liu,Ya-Hong(*)Genetic Analysis of the IncX4 Plasmids: Implications for a Unique Pattern in the mcr-1 AcquisitionScientific Reports2017.2.17

(3) Zhou, Yu-FengTao, Meng-TingFeng, YoujunYang, Run-ShiLiao, Xiao-PingLiu, Ya-HongSun, Jian(*)Increased activity of colistin in

combination with amikacin against Escherichia coli co-producing NDM-5 and MCR-1Journal of Antimicrobial Chemotherapy2017.2.20724):0~0

(4) Chen, YiHu, DaxingZhang, QijingLiao, Xiao-PingLiu, Ya-Hong(*)Sun, Jian(*)Efflux Pump Overe­xpression Contributes to Tigecycline Heteroresistance in Salmonella enterica serovar TyphimuriumFrontiers in Cellular and Infection Microbiology2017.2.17737

(5) Sun, Jian(#)Li, Xing-Ping(#)Yang, Run-ShiFang, Liang-XingHuo, WeiLi, Shu-MinJiang, PengLiao, Xiao-PingLiu, Ya-Hong(*)Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.Antimicrobial Agents and Chemotherapy2016.8.01608):5014~5017

(6) Li, Xing-PingFang, Liang-XingSong, Jia-QiXia, JingHuo, WeiFang, Jin-TaoLiao, Xiao-PingLiu, Ya-HongFeng, Youjun(*)Sun, Jian(*)Clonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China.Scientific Reports2016.12.5638511~38511

(7) Yang, Run-ShiFeng, YoujunLv, Xiao-YueDuan, Jia-HongChen, JingFang, Liang-XingXia, JingLiao, Xiao-PingSun, Jian(*)Liu, Ya-Hong(*)Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and

ST156 from a Single Muscovy Duck (Cairina moschata).Antimicrobial Agents and

Chemotherapy2016.11.016011):6899~6902

(8) Huang, TingXu, YingZeng, JieZhao, Dong-HaoLi, LiangLiao, Xiao-PingLiu, Ya-Hong(*)Sun, Jian(*)Low-Concentration Ciprofloxacin Selects Plasmid-Mediated Quinolone Resistance Encoding Genes and Affects Bacterial Taxa in Soil Containing Manure.Frontiers in Microbiology2016.01.0171730~1730

(9) Yang, Qiu EWalsh, Timothy RutlandLiu, Bao TaoZou, Meng TingDeng, HuiFang, Liang XingLiao, Xiao PingSun, Jian(*)Liu, Ya Hong(*)Complete Sequence of the FII Plasmid p42-2, Carrying blaCTX-M-55, oqxAB, fosA3, and floR from Escherichia coli.Antimicrob Agents Chemother2016.7.01607):4336~4338

(10) Fang, LiangxingLi, XingpingLi, LiangLi, ShuminLiao, XiaopingSun, Jian(*)Liu, Yahong(*)Co-spread of metal and antibiotic resistance within ST3-IncHI2 plasmids from E. coli isolates of food-producing animals.Scientific Reports2016.5.4625312~25312

(11) Chen, Mu-YaLira, FelipeLiang, Hua-QingWu, Rui-TingDuan, Jia-HongLiao, Xiao-PingMartinez, Jose LLiu, Ya-Hong(*)Sun, Jian(*)Multilevel selection of bcrABDR-mediated bacitracin resistance in Enterococcus faecalis from chicken farms.Scientific Reports2016.10.12634895~34895

(12) Sun, Jian(#)Li, Liang(#)Liu, BaotaoXia, JingLiao, XiaopingLiu,Yahong(*)Development of aminoglycoside and beta-lactamase resistance among intestinal microbiota of swine treated with lincomycin, chlortetracycline, and amoxicillin.Front Microbiol2014.01.015580~580

(13) Sun, Jian(#)Deng, Hui(#)Li, LiangChen, Mu-YaFang, Liang-XingYang, Qiu-ELiu, Ya-Hong(*)Liao, Xiao-Ping(*)Complete nucleotide sequence of cfr-carrying IncX4 plasmid pSD11 from Escherichia coli.Antimicrob Agents Chemother2015.1.01591):738~741

(14) Sun, Jian(#)Xiao, Xia(#)Huang, Rui-JuanYang, TaoChen, YiFang, XiHuang, TingZhou, Yu-FengLiu, Ya-Hong(*)In vitro Dynamic Pharmacokinetic/Pharmacodynamic (PK/PD) study and COPD of Marbofloxacin against Haemophilus parasuis.BMC Veterinary Research2015.12.111293~293

(15) Sun, JYuan, LZhu, LHe, LLuo, XWang, RLiu, Y(*)Pharmacokinetics and bioavailability of valnemulin in Muscovy ducks (Cairina moschata).Br Poult Sci2012.01.01533):374~378

(16) Sun, Jian(#)Liao, Xiaoping(#)Li, LuluYang, YurongLiu, BaotaoWang, YangZhu, HengqianZhu, LimengTu, ChuntingLiu, Yahong(*)Emergence of pandemic B2-O25b-ST131 Escherichia coli harbouring blaCTX-M-3, blaCTX-M-27 and qnrS1 genes.J Med Microbiol2011.11.0160Pt 11):1711~1712

(17) Gao, Rongsui(#)Hu, Yongfei(#)Li, Zhencui(#)Sun, Jian(#)Wang, QingjingLin, JingxiaYe, HuiyanLiu, FeiSrinivas, SwaminathLi, DefengZhu, BaoliLiu, Ya-HongTian, Guo-BaoFeng, Youjun(*)Dissemination and Mechanism for the MCR-1 Colistin Resistance.PLoS Pathogens2016.11.011211):e1005957~e1005957

(18) Sun, JianLiao, Xiao-PingLiu, Ya-Hong(*)Feng, Youjun(*)One Health: An Approach to Resolving Antibiotic ResistanceInfect Dis Transl Med2016.9.623):122~124

(19) Fang, Liang-Xing(#)Sun, Jian(#) Li, LiangDeng, HuiHuang,TingYang, Qiu-ELi, XueChen, Mu-YaLiao, Xiao-PingLiu, Ya-Hong(*)Dissemination of the chromosomally encoded CMY-2 cephalosporinase gene in Escherichia coli isolated from animals.International Journal of Antimicrobial Agents2015.8.01462):209~213

(20) Chen, Yi(#)Sun, Jian(#)Liao, Xiao-PingShao, YangLi, LiangFang, iang-XingLiu, Ya-Hong(*)Impact of enrofloxacin and florfenicol therapy on the spread of OqxAB gene and intestinal microbiota in chickens.Veterinary Microbiology2016.8.301921~9

(21) Xia, Jing(#)Sun, Jian(#)Cheng, KeLi, LiangFang, Liang-XingZou, Meng-TingLiao, Xiao-PingLiu, Ya-Hong(*)Persistent spread of the rmtB 16S rRNA methyltransferase gene among Escherichia coli isolates from diseased food-producing animals in China.Vet Microbiol2016.5.3018841~46

(22) Xiao, Xia(#)Sun, Jian(#)Chen, YiZou, MengtingZhao, Dong-HaoLiu, Ya-Hong(*)Ex vivo pharmacokinetic and pharmacodynamic analysis of valnemulin against Mycoplasma gallisepticum S6 in Mycoplasma gallisepticum and Escherichia coli co-infected chickens.Veterinary Journal2015.4.012041):54~59

(23) Deng, Hui(#)Sun, Jian(#)Ma, JunLi, LiangFang, Liang-XingZhang, QijingLiu, Ya-HongLiao, Xiao-Ping(*)Identification of the multi-resistance gene cfr in Escherichia coli isolates of animal origin.PLos One2014.01.0197):e102378~e102378

(24) Xiao, Xia(#)Sun, Jian(#)Yang, TaoFang, XiWu, DongXiong, Yan QCheng, JieChen, YiShi, WeiLiu, Ya-Hong(*)In vivo pharmacokinetic/pharmacodynamic profiles of valnemulin in an experimental intratracheal Mycoplasma gallisepticum infection model.Antimicrobial Agents

and Chemotherapy2015.7.01597):3754~3760

(25) Yang, Qiu-E(#)Sun, Jian(#)Li, LiangDeng, HuiLiu, Bao-TaoFang, Liang-XingLiao, Xiao-PingLiu, Ya-Hong(*)IncF plasmid diversity in multi-drug resistant Escherichia coli strains from animals in China.Frontiers in Microbiology2015.01.016964~964

(26) Yuan, Liguo(#)Sun, Jian(#)Wang, RuiSun, LihuaZhu, LixiangLuo, XianyangFang, BinghuLiu, Yahong(*)Pharmacokinetics and bioavailability of cefquinome in healthy ducks.American Journal of Veterinary Research2011.1.01721):122~126

(27) Xiao, Xia(#)Sun, Jian(#)Yang, TaoFang, XiCheng, JieXiong, Yan QLiu, Ya-Hong(*)Pharmacokinetic/Pharmacodynamic Profiles of Tiamulin in an Experimental Intratracheal Infection Model of Mycoplasma gallisepticum.Front Vet Sci2016.01.01375~75

(28) Xiao, Xia(#)Sun, Jian(#)Chen, YiHuang, Rui-JuanHuang, TingQiao, Guilin GaryZhou, Yu-FengLiu, Ya-Hong(*)In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis.BMC Veterinary Research2015.2.131133~33

(29) Yang, Shou-Shen(#)Sun, Jian(#)Liao, Xiao-PingLiu, Bao-TaoLi, Lu-LuLi, LiangFang, Liang-XingHuang, TingLiu, Ya-Hong(*)Co-location of the erm(T) gene and blaROB-1 gene on a small plasmid in Haemophilus parasuis of pig origin.Journal of Antimicrobial Chemotherapy2013.8.01688):1930~1932

(22) Li, Liang(#)Sun, Jian(#)Liu, BaotaoZhao, DonghaoMa, JunDeng, HuiLi, XueHu, FengyangLiao, XiaopingLiu, Yahong(*)Quantification of lincomycin resistance genes associated with lincomycin residues in waters and soils adjacent to representative swine farms in China.Frontiers in Microbiology2013.01.014364~364

(30) Zhang, Sen(#)Sun, Jian(#)Liao, Xiao-PingHu, Qian-JiangLiu, Bao-TaoFang, Liang-XingDeng, HuiMa, JunXiao, XiaZhu, Heng-QianLiu, Ya-Hong(*)Prevalence and plasmid characterization of the qnrD determinant in Enterobacteriaceae isolated from animals, retail meat products, and humans.Microbial Drug Resistance2013.8.01194):331~335

 

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